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        Merck, Eli Lilly and AstraZeneca have similarly suspended or outright canceled investments in the U.K. in the past week after a sizeable increase in a mandatory levy in the region. 
    
        
    
        
    
        
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        Seven biotech unicorns are advancing AI-powered drug discovery and development—but must contend with a difficult investing environment where competition is steep and the usual roads to exit are uncertain.
    
        
    
        
    
        
    
        More than thirty years since its 1993 founding, Catherine Owen Adams and Elizabeth Thompson—the R&D combo that has led Acadia since last year—are managing two products on the market and a pipeline estimated to be worth an additional $12 billion in sales.
    
        
    
        
    
        
    
        New data and analyses presented at the American Diabetes Association’s annual meeting highlight the priorities for the next generation of weight loss medicines: muscle preservation, limited side effects and novel targets.
    
        
    
        
    
        
    Job Trends
        
        
        
    
        Promega Corporation launched its annual report on how the biotechnology manufacturer is supporting sustainability, employee wellbeing and global communities.
    
        
    
        
    
        
    FROM OUR EDITORS
        
        
            Read our takes on the biggest stories happening in the industry.
        
        
    
        Novo Nordisk, under new CEO Maziar Mike Doustdar, has a new attitude. It’s making Pfizer livid.
    
        
    
        
    
        
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        The FDA Adverse Event Reporting System, which Commissioner Marty Makary called “clunky,” previously published updates on a quarterly basis.
    
        
    
        
    
        
    
        The mad rush for safe and effective obesity drugs has winners—including Eli Lilly’s Zepbound and Novo Nordisk’s Wegovy—and losers. Here are five molecules that never made it to the market.
    
        
    
        
    
        
    
        While it’s impossible to make apples-to-apples comparisons of the many obesity candidates with so many differences across clinical trials, we at BioSpace are giving it our best shot.
    
        
    
        
    
        
    
        With results from highly anticipated trials of Eli Lilly’s orforglipron and Viking Therapeutics’ VK2735 “underwhelming” investors, William Blair’s Andy Hsieh predicts weight loss pills will play a bigger role in low- and middle-income countries than in the U.S.
    
        
    
        
    
        
    
        There’s still much more to come from the White House on tariffs, but the European Union has now reached a trade agreement with the U.S.
    
        
    
        
    
        
    
        The drug, for hereditary angioedema, is Ionis’ second wholly owned asset.
    
        
    
        
    
        
    
        Vanda claims that two generics to its sleep disorder drug Hetlioz were approved despite inadequate data and is requesting that FDA Commissioner Marty Makary revisit the decision. 
    
        
    
        
    
        
    
        Krystal Biotech’s decision follows the FDA’s rejection last month of Replimune’s RP1, which works similarly to Krystal Biotech’s KB707. The biotech said this has introduced “heightened uncertainty” regarding a potential accelerated pathway for the candidate. 
    
        
    
        
    
        
    
        Among the problems cited were cat hair, bacterial contamination and instrument defects.
    
        
    
        
    
        
    
        Washington has had notable life sciences job growth over the past 10 years, according to a Life Science Washington report. The association’s CEO and a biopharma CEO discuss what makes the state stand out, including its talent pool, AI leadership and entrepreneurship support.
    
        
    
        
    
        
     
         
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
