Pre-Clinical Research
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There are plenty of great scientific research stories out this week. Here’s a look at just a few of them.
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Researchers at Yale University were able to restore basic cellular activity in the brains of pigs only hours after their deaths. They published their work in the journal Nature.
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Inovio Publishes Cancer Killing Data of Its Transformative DNA-encoded Bi-specific T Cell Engagers (dBiTEs™) in a Peer-reviewed Journal
4/18/2019
Data demonstrates tumor-clearing ability of Inovio's dBiTE
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EXCLUSIVE: Flagship Pioneering Company Kintai Therapeutics Focuses on Enteric Therapeutics
4/16/2019
The vast majority of immune cells are found in the gut but historically, the gut has been viewed as a liability to drug development. The question of whether or not greater understanding of harnessing the gut could drive more promising drug development has led to the formation of a new company, Ki... -
How Biotechnology Can Save the Planet
4/16/2019
There is a tendency to look at biotech as being all about developing drugs. And, of course, that is the primary focus of BioSpace. However, from time to time it’s a good idea to remind ourselves that biotech can and does have broader applications besides medicines, and can, in fact, impact our da... -
Biomica Initiates Pre-clinical Studies in Its Immuno-oncology Program
4/16/2019
Aims to augment current cancer therapies by altering patients' gut microbiome to improve response
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Eureka Therapeutics Announces Publication of Preclinical Study Demonstrating Selective Depletion of Tregs Using Foxp3 Targeting TCR-mimic Antibody
4/15/2019
Eureka Therapeutics, Inc., a clinical stage biotechnology company developing novel T-cell therapies that harness the evolutionary power of the immune system, today announced the publication of a proof-of-concept study in OncoImmunology entitled “Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody.”
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Goldfinch Bio Presents Data Enabling the Advancement of Innovative Approaches to the Treatment of Kidney Disease at the International Society of Nephrology World Congress 2019
4/15/2019
TRPC5 Inhibition with GFB-887 Protects Against Podocyte Injury and Proteinuria Associated with Focal Segmental Glomerulosclerosis and Treatment-resistant Minimal Change Disease
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When the mice were dosed with ketamine, the effects of depression were reversed. Ketamine restored synapses in the brains of the mice.
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There are plenty of great scientific research stories out this week. Here’s a look at just a few of them.
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89bio Announces Preclinical Data That Demonstrate Potential Utility of BIO89-100 for Treatment of NASH
4/12/2019
Data presented in Late-Breaking Presentation at the EASL International Liver Congress™ [11-April-2019] SAN FRANCISCO and HERZLIYA, Israel , April 11, 2019 /PRNewswire/ -- 89bio LTD, a clinical-stage biopharmaceutical company focused on nonalcoholic steatohepatitis (NASH) and other liver and metabolic disorders, today announced that preclinical data of its investigat
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Arrowhead Preclinical Data Demonstrates RNAi Therapy Prevents and Reverses Alpha-1 Liver Disease at The International Liver Congress™
4/12/2019
Arrowhead Pharmaceuticals Inc. presented preclinical data at The International Liver Congress™ 2019, the annual meeting of the European Association for the Study of the Liver, demonstrating that sustained reduction of mutant Z-AAT protein by RNA interference substantially reversed the alpha-1 antitrypsin deficiency disease phenotype in the PiZ mouse model.
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One of the many tricks the AIDS virus, HIV, uses to proliferate so aggressively is it hides from the body’s immune system. Until now, this has largely been a mystery.
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Seattle-based Ambry Genetics recently presented data at the American College of Medical Genetics and Genomics annual meeting describing the results of supplemental RNA genetic testing data.
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Enanta Pharmaceuticals Presents New Preclinical Data on Compounds Targeting Hepatitis B Virus and Non-Alcoholic Steatohepatitis at The International Liver Congress™ 2019
4/11/2019
Enanta Pharmaceuticals, Inc. announced that new preclinical data from Enanta’s wholly-owned development programs for hepatitis B virus and non-alcoholic steatohepatitis will be presented at The International Liver Congress™ 2019, in Vienna, Austria.
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Gelesis Presents Preclinical Data Showing Proprietary Hydrogel Prevents Harmful Effects of a High-Fat Diet
4/11/2019
Mice fed high-fat diet and treated with Gel-B (GS300 prototype) hydrogel were protected against the development of fatty liver and associated metabolic disorders
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Metabo-oncology is the study of the effects that metabolic dysfunction and obesity have on cancer and cancer treatments. This includes both how they affect those who already have cancer as well as how they may increase the odds of one getting cancer later on in life.
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There are a lot of ways to kill viruses, but it’s not that easy to kill them in the air. For the most part, if you want to prevent viruses from infecting someone, or from entering a room, for example, you use a face mask or air filters.
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Alligator Bioscience to Present New Preclinical Data on ATOR-1015 at PEGS Boston
4/10/2019
Tumor-localizing properties of bispecific antibody demonstrated by live imaging
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Pliant Therapeutics Reports Positive Results of Phase 1 Clinical Study Support Advancement of PLN-74809 for Idiopathic Pulmonary Fibrosis
4/9/2019
Preclinical Studies Demonstrating Anti-fibrotic Effect of Integrin Inhibitor to be Presented at American Thoracic Society International Conference