Find Therapeutics, a new drug development company dedicated to breakthrough therapies against rare diseases launches in Montreal
The new company raises initial capital to develop transmembrane peptides against GPCRs to address high unmet needs.
MONTREAL, June 8, 2020 /CNW Telbec/ - CTI Life Sciences, along with partners adMare BioInnovations, Domain Therapeutics and PeptiMimesis Pharma, have come together to establish a new Montreal-based drug discovery and development company, Find Therapeutics, dedicated to the development of the next generation of GPCR allosteric modulators to treat rare diseases.
Now being launched with seed funding from CTI Life Sciences, adMare BioInnovations and Domain Therapeutics, and with an initial focus on inflammatory and fibrotic diseases of the airways, liver and gastrointestinal systems, Find Therapeutics is based on a set of novel technologies that capitalize on deciphering disease-modifying GPCR pharmacology: modulation by transmembrane peptides, precise ligand signalling, disease-contextual cellular systems and advanced molecular design. GPCRs represent one of the most important druggable target classes, yet their full potential remains underexploited due to poor understanding of their cellular signalling.
"We are very excited about building this new company based on an innovative approach to discover transmembrane GPCR drugs. We believe this approach will enable the discovery of new therapies that we will first apply to rare disease indications," said Dr. Laurence Rulleau Partner, CTI Life Sciences Fund, and President, Find Therapeutics. "We are also very proud of this partnership with members of the life science ecosystem bringing together multiple talents."
Find Therapeutics sourced an original transmembrane peptide-based-technology developed by PeptiMimesis Pharma in France, and a first transmembrane peptide product discovered at the University of Illinois in Chicago. The company will also benefit from bioSens-AllTM, a proprietary GPCR technology platform of Domain Therapeutics, operated by its Montreal-based site, which revolves around the spatiotemporal monitoring of GPCR proximal events directly linked to GPCR activation. The result is a unique drug discovery engine that forms the foundation of Find Therapeutics.
Gordon C. McCauley, President and Chief Executive Officer of adMare BioInnovations, commented, "As Canada's global life sciences venture, an essential part of adMare's mission is to source therapeutically and commercially promising research from leading academic and biotech partners to create new companies of scale. This global partnership is an excellent example of how our model of collaboration is advancing new therapeutics and driving the growth of our Canadian life sciences industry."
"We are extremely pleased by the creation and financing of Find Therapeutics, which will use two technologies, developed under the leadership of Domain Therapeutics in France and in Quebec, to discover a novel class of therapeutic agents for the benefit of the patients," said Dr. Pascal Neuville, Chief Executive Officer of Domain Therapeutics. "As a major shareholder of PeptiMimesis Pharma, we are convinced that the transmembrane-peptide approach will be efficiently further developed in the rich biotech ecosystem of Montreal, a region which holds very valuable actors in the field – and the incorporation of Find Therapeutics is a nice illustration of this dynamic."
Dr. Marjorie Sidhoum, Chief Executive Officer of PeptiMimesis added, "As the first developer of the GPCR transmembrane peptide technology, PeptiMimesis is glad to see the advancement of this innovative therapeutic approach pursued by Find Therapeutics. All PeptiMimesis stakeholders are very excited to join this endeavour."
Dr. Youssef Bennani, Chief Scientific Officer of adMare BioInnovations, will also act as Find's Interim Chief Executive Officer of the company. Dr. Bennani brings a solid experience in pharmaceutical R&D, as well as business acumen and corporate governance tenure (Chairman of the BOD at Domain Therapeutics, and Board member at Bellus Health). Trained as chemist, he most recently retired from Vertex Pharmaceuticals as Site Head and VP-R&D (Vertex Pharmaceuticals Canada), prior to which he had served as VP-Drug Innovation at Vertex Pharmaceuticals Inc. in Cambridge, MA. He also had tenures at Athersys, Abbott (now AbbVie) and Ligand Pharmaceuticals. He can be reached at email@example.com.
Visit www.findtherapeutics.com for more details about Find Therapeutics.
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