Background on siRNA
Identification and characterization of mammalian siRNA mechanisms that control protein production has resulted in an important new area of research, opening up the potential to create entirely new classes of therapeutics that can specifically target genes responsible for a variety of disease states. This breakthrough provides the ability to create siRNA-based drugs that can lead to innovative treatments for many of the most devastating diseases such as cancer and genetic disorders.
Long-term siRNA delivery systems offer the potential of increased safety and efficacy, improved patient convenience (for example, with less dosing or injections), enhanced compliance and ultimately better therapeutic response. In general, the field of siRNA is not yet fully focused on long-term delivery, but it is expected that for many disease indications this will increasingly become a focus as siRNA based products get closer to market.
"We are thrilled to be working with the team at EGEN and are excited about the compelling data generated to date. At SurModics, we like to maintain a balance of cutting edge innovation. Many of our efforts are focused on creating new technologies and products for customers in the relative near-term. Others, however, like this extended release of siRNA, are ones where we intend to establish a leadership technology position for customers 2, 5, and 10 years in the future," said Arthur J. Tipton, Ph.D., Chief Scientific Officer of SurModics.
Khursheed Anwer, Ph.D., President and Chief Scientific Officer of EGEN added, "The program with SurModics employs our TheraSilence technology for sustained delivery of therapeutic RNAi. The extended release data generated from the collaborative work is impressive and warrants continuation of this exciting joint effort. A key mission for EGEN is to apply our broad-based RNAi delivery technology platform to create novel solutions for human diseases."
About EGEN, Inc.
EGEN, Inc. is a privately held biopharmaceutical company focused on developing therapeutics for the treatment of human diseases, particularly cancer. The Company specializes in the delivery of therapeutic nucleic acids (DNA and RNAi) aimed at specific disease targets via its proprietary TheraPlas and TheraSilence technologies. EGEN has a significant portfolio of functionalized, biocompatible synthetic delivery systems for use in combination with DNA, RNA and other biomacromolecules for therapeutic applications. EGEN is located in Huntsville, Alabama in the Hudson-Alpha Institute of Biotechnology. More information about the company can be found at www.egeninc.com
About SurModics, Inc.
SurModics' vision is to extend and improve the lives of patients through technology innovation. The Company partners with the world's foremost medical device, pharmaceutical and life science companies to develop and commercialize innovative products that result in improved diagnosis and treatment for patients. Core offerings include: drug delivery technologies (coatings, microparticles, nanoparticles, and implants); surface modification coating technologies that impart lubricity, prohealing, and biocompatibility capabilities; and components for in vitro diagnostic test kits and specialized surfaces for cell culture and microarrays. SurModics is headquartered in Eden Prairie, Minnesota and its SurModics Pharmaceuticals subsidiary is located in Birmingham, Alabama. For more information about the Company, visit www.surmodics.com. The content of SurModics' website is not part of this release or part of any filings the Company makes with the SEC.
Safe Harbor for Forward-Looking Statements for SurModics, Inc.
This press release contains forward-looking statements. Statements that are not historical or current facts, including statements about beliefs and expectations, are forward-looking statements. Forward-looking statements involve inherent risks and uncertainties, and important factors could cause actual results to differ materially from those anticipated, including those identified under "Risk Factors" in Part I, Item 1A of our Annual Report on Form 10-K for the fiscal year ended September 30, 2009, and updated in our subsequent reports filed with the SEC. These reports are available in the Investors section of our website at www.surmodics.com and at the SEC website at www.sec.gov. Forward-looking statements speak only as of the date they are made, and we undertake no obligation to update them in light of new information or future events.
SOURCE EGEN, Inc.
