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        Merck, Eli Lilly and AstraZeneca have similarly suspended or outright canceled investments in the U.K. in the past week after a sizeable increase in a mandatory levy in the region. 
    
        
    
        
    
        
    FEATURED STORIES
        
        
        
    
        From Wall Street to real estate to a “big, ugly” pharma building, Mayo Venture Partner Audrey Greenberg reflects on a career defined by taking a leap at just the right moment.
    
        
    
        
    
        
    
        Some of the most high-profile acquisitions in recent years have involved women-fronted biotechs. BioSpace reviews five of the most notable here.
    
        
    
        
    
        
    
        Seven biotech unicorns are advancing AI-powered drug discovery and development—but must contend with a difficult investing environment where competition is steep and the usual roads to exit are uncertain.
    
        
    
        
    
        
    Job Trends
        
        
        
    
        Novo Holdings, a leading life science investor, announced that its Boston office has been named a 2024 Best Place to Work by the Boston Business Journal.
    
        
    
        
    
        
    FROM OUR EDITORS
        
        
            Read our takes on the biggest stories happening in the industry.
        
        
    
        After Emma Walmsley steps down as GSK CEO in January, Vertex Pharma’s Reshma Kewalramani will be the sole female CEO at a top-20 pharma company. Still, there are many prominent women in pharma that could someday break through again.
    
        
    
        
    
        
    THE LATEST
    
    
        Arnatar is developing ART4, an antisense oligonucleotide that ups the expression of its target protein to treat a rare disease called Alagille syndrome.
    
        
    
        
    
        
    
        Thousands of employees across the Department of Health and Human Services are set to lose their collective bargaining rights in a move that American Federation of Government Employees national president Everett Kelley called “illegal and immoral.”
    
        
    
        
    
        
    
        Earlier this month, the FDA backed off on a pause in shipments of the chikungunya vaccine Ixchiq to older adults. Now, the regulator has reversed course.
    
        
    
        
    
        
    
        The FDA Adverse Event Reporting System, which Commissioner Marty Makary called “clunky,” previously published updates on a quarterly basis.
    
        
    
        
    
        
    
        The mad rush for safe and effective obesity drugs has winners—including Eli Lilly’s Zepbound and Novo Nordisk’s Wegovy—and losers. Here are five molecules that never made it to the market.
    
        
    
        
    
        
    
        While it’s impossible to make apples-to-apples comparisons of the many obesity candidates with so many differences across clinical trials, we at BioSpace are giving it our best shot.
    
        
    
        
    
        
    
        With results from highly anticipated trials of Eli Lilly’s orforglipron and Viking Therapeutics’ VK2735 “underwhelming” investors, William Blair’s Andy Hsieh predicts weight loss pills will play a bigger role in low- and middle-income countries than in the U.S.
    
        
    
        
    
        
    
        There’s still much more to come from the White House on tariffs, but the European Union has now reached a trade agreement with the U.S.
    
        
    
        
    
        
    
        The drug, for hereditary angioedema, is Ionis’ second wholly owned asset.
    
        
    
        
    
        
    
        Vanda claims that two generics to its sleep disorder drug Hetlioz were approved despite inadequate data and is requesting that FDA Commissioner Marty Makary revisit the decision. 
    
        
    
        
    
        
     
         
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
