The modular Asia flow chemistry system from Syrris proved key to the success of a recently described process for accelerated total synthesis of spirodienal A and spirangien A methyl ester. Developed by the Ley Group at the Department of Chemistry, University of Cambridge, UK – and recently published in Angewandte Chemie International Edition1 – the groundbreaking work describes the use of powerful flow chemistry techniques for complex multi-stage synthesis of spirocyclic polyketides.
The flexible Asia system was crucial to the success of the study, offering a variety of flow techniques – including gas-liquid and solid phase chemistries, liquid-liquid extraction and continuous work-up – to enable faster reaction optimization and telescoping of reaction steps. Researchers benefitted from the Asia Pump’s capacity to smoothly handle low boiling point solvents, as well as rapid mixing and continuous work-up in glass microreactors with the advanced Asia FLLEX (Flow Liquid Liquid Extraction). This set-up allowed synthesis of essential, complex coupling fragments using newly developed flow chemistry methods for automated reagent addition, silylation, crotylation, ozonolysis, olefination and oxidation, allowing these vital building blocks to be produced faster and more safely, with higher yields compared to batch reactions.
1 Newton, S., Carter, C. F., Pearson, C. M., de C. Alves, L., Lange, H., Thansandote, P. and Ley, S. V. (2014), Accelerating Spirocyclic Polyketide Synthesis using Flow Chemistry. Angew. Chem. Int. Ed., 53: 4915–4920. doi: 10.1002/anie.201402056
Syrris Limited
Syrris is world renowned for excellence in chemical reactor systems and is a world leader in flow chemistry systems. Established in 2001, Syrris employs over 30 scientists and engineers at its facility in Royston (near Cambridge, UK) and has offices in the US, Japan, India and Brazil plus over 30 distributors worldwide.
Syrris develops laboratory automation products for research and development chemists in industries such as pharma, petrochem, agrochem, fine chemical synthesis etc. as well as academia. Syrris products are used in a wide variety of applications and laboratories including process, discovery, crystallization, process safety, scale-up and many more.
Syrris products include the innovative range of fully automated batch reactor products (Atlas), a manually operated jacketed reactor platform (Globe) and flow chemistry systems (Asia and Africa). In recognition of its technological achievements, Syrris has been awarded the “Eastern Region’s UKTI Best Established Exporter” and the “Most Outstanding Export Achievement” at the Global Opportunity Conference on International Trade. Syrris’ Asia Flow Chemistry system was the recipient of a prestigious 2012 R&D award.
Help employers find you! Check out all the jobs and post your resume.
