Two different agents that have little individual effect on lung cancer when tested in low doses in the lab and in animals have a synergistic impact when combined together, say researchers at The University of Texas M. D. Anderson Cancer. They say this new therapeutic recipe might show potential in disarming the nation’s leading cancer killer. The study, published in the October 20 issue of the Journal of the National Cancer Institute, tested an experimental targeted therapy, the farnesyltransferase inhibitor SCH66336, and an agent, the insulin-like growth factor binding protein-3 (IGFBP-3), and found that even at a combined low dose, tumor size was reduced by half in mice implanted with human lung tumors.
