25 November 2009, Oxford, UK: Oxford Expression Technologies Ltd (OET), a leading provider of baculovirus-based protein expression products and services, has signed research collaboration agreements with ParaTechs and LifeSensors. The projects aim to enhance and expand OET’s highly successful flashBAC™ portfolio of baculovirus protein expression systems.
OET’s propriety flashBAC technology is a baculovirus based recombinant system enabling the production of multiple recombinant viruses in a one-step process. The system is suitable for small and large scale protein expression and is already enabling scientists to produce proteins faster, more easily and cost-effectively.
The collaboration with ParaTechs will investigate the potential impact of expressing a Vankyrin gene in tandem with a foreign gene on the quality and yield of the foreign protein and to evaluate whether any benefits are enhanced by using the flashBAC system, which is already known to increase recombinant protein yields beyond those achieved using a conventional vector. This project will also compare flashBAC vectors expressing Vankyrin gene-fusions in ParaTechs Vankyrin-Enhanced cell lines, with standard insect cell lines.
Under the agreement with LifeSensors, the two companies will work together to incorporate a SUMO (small ubiquitin-like modifier) tag into the flashBAC system, and evaluate whether this increases the quality of protein produced. The use of SUMO as a fusion tag has been shown to dramatically increase yield and solubility of protein in more traditional systems. The two companies are hoping that SUMO will create an even more powerful flashBAC system.
“The collaborations form part of our ongoing strategy of developing new and improved protein expression systems for our customers,” said James Bernard, Director, OET. “We’re delighted to be working alongside these companies and look forward to generating exciting results.”
OET was recently named ‘Best Early Stage Biotech’ at the Oxford and South-East Bioscience Awards, in recognition of its introduction of new technology with commercial value and development of a revenue stream.
About Oxford Expression Technologies
Oxford Expression Technologies (OET) is a biotechnology company and centre of excellence for baculovirus protein expression. Specialising in the use of the baculovirus expression vector system, a eukaryotic expression system that can express a large variety of recombinant proteins, OET provides protein expression products, services and consultancy to many global pharmaceutical companies. OET’s proprietary flashBAC technology enables large amounts of a given protein to be produced in culture. The Company’s internationally renowned expertise and products enable proteins to be produced faster, more easily and cost-effectively using automated and high-throughput methods compared with other baculovirus systems. This contributes to the development of new drugs and research targeted towards understanding how proteins work in health and disease.
The company was founded in 2007 as the result of collaboration between Oxford Brookes University and the Natural Environment Research Council to provide researchers with custom proteins for research purposes. For further details about the Company’s services and products, please visit http://www.oetltd.com/
OET’s propriety flashBAC technology is a baculovirus based recombinant system enabling the production of multiple recombinant viruses in a one-step process. The system is suitable for small and large scale protein expression and is already enabling scientists to produce proteins faster, more easily and cost-effectively.
The collaboration with ParaTechs will investigate the potential impact of expressing a Vankyrin gene in tandem with a foreign gene on the quality and yield of the foreign protein and to evaluate whether any benefits are enhanced by using the flashBAC system, which is already known to increase recombinant protein yields beyond those achieved using a conventional vector. This project will also compare flashBAC vectors expressing Vankyrin gene-fusions in ParaTechs Vankyrin-Enhanced cell lines, with standard insect cell lines.
Under the agreement with LifeSensors, the two companies will work together to incorporate a SUMO (small ubiquitin-like modifier) tag into the flashBAC system, and evaluate whether this increases the quality of protein produced. The use of SUMO as a fusion tag has been shown to dramatically increase yield and solubility of protein in more traditional systems. The two companies are hoping that SUMO will create an even more powerful flashBAC system.
“The collaborations form part of our ongoing strategy of developing new and improved protein expression systems for our customers,” said James Bernard, Director, OET. “We’re delighted to be working alongside these companies and look forward to generating exciting results.”
OET was recently named ‘Best Early Stage Biotech’ at the Oxford and South-East Bioscience Awards, in recognition of its introduction of new technology with commercial value and development of a revenue stream.
About Oxford Expression Technologies
Oxford Expression Technologies (OET) is a biotechnology company and centre of excellence for baculovirus protein expression. Specialising in the use of the baculovirus expression vector system, a eukaryotic expression system that can express a large variety of recombinant proteins, OET provides protein expression products, services and consultancy to many global pharmaceutical companies. OET’s proprietary flashBAC technology enables large amounts of a given protein to be produced in culture. The Company’s internationally renowned expertise and products enable proteins to be produced faster, more easily and cost-effectively using automated and high-throughput methods compared with other baculovirus systems. This contributes to the development of new drugs and research targeted towards understanding how proteins work in health and disease.
The company was founded in 2007 as the result of collaboration between Oxford Brookes University and the Natural Environment Research Council to provide researchers with custom proteins for research purposes. For further details about the Company’s services and products, please visit http://www.oetltd.com/
