HACKENSACK, N.J., Nov. 4 /PRNewswire-FirstCall/ -- DOV Pharmaceutical, Inc. announced today that its Senior Director of Pharmacology, Dr. Anthony Basile, will present a poster entitled "Bicifadine: Preclinical Characteristics of a Novel, Non-Opioid Analgesic" on November 5, 2005, at the 8th International Conference on the Mechanisms and Treatment of Neuropathic Pain in San Francisco.
The poster illustrates the broad spectrum of analgesic activity produced by bicifadine in a variety of animal models that are predictive of efficacy treating acute and chronic pain states. For example, bicifadine is a potent analgesic following oral administration as measured by the Randall Selitto and formalin tests. Both procedures are commonly used to assess the effectiveness of drugs in the treatment of acute pain. Moreover, bicifadine reduces both mechanical hyperalgesia and allodynia following spinal nerve ligation in rats ("Chung Model") and mechanical hyperalgesia produced by experimentally-induced diabetes, two well-established models of neuropathic pain. These findings indicate that bicifadine may be effective in treating many of the painful symptoms produced by diabetes and other conditions resulting in peripheral neuropathies. Bicifadine is a novel norepinephrine and serotonin reuptake inhibitor, non-narcotic analgesic currently in Phase III clinical trials for the treatment of both acute and chronic pain conditions.
The poster will be archived and available in the investor relations section of DOV's website: http://www.dovpharm.com after the conference for 90 days.
About DOV
DOV is a biopharmaceutical company focused on the discovery, acquisition, development and commercialization of novel drug candidates for central nervous system and other disorders, including cardiovascular, that involve alterations in neuronal processing. Our product candidates address some of the largest pharmaceutical markets in the world including insomnia, pain and depression. Our partner Neurocrine has filed two NDA's for the use of DOV's compound indiplon for the treatment of insomnia.
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* Demonstrate the safety and efficacy of product candidates at each stage of development; * meet our development schedule for our product candidates, including with respect to clinical trial initiation, enrollment and completion; * develop an acceptable development plan under and otherwise achieve the results contemplated by the recent amendment to the existing license agreement with Merck; * meet applicable regulatory standards and receive required regulatory approvals on our anticipated time schedule or at all; * meet obligations and required milestones under our license and other agreements; * obtain and maintain collaborations as required with pharmaceutical partners; * obtain substantial additional funds; * obtain and maintain all necessary patents or licenses; and * produce drug candidates in commercial quantities at reasonable costs and compete successfully against other products and companies.
Factors that may cause our actual results to differ materially from our forward-looking statements include (i) one or more of our product candidates could be shown to cause harmful side effects, (ii) one or more of our product candidates may not exhibit the expected therapeutic results, (iii) we or the FDA may place on clinical hold one or more of our clinical trials, and neither we nor the agency may determine to lift such hold, (iv) patient recruitment may be slower than expected or patients may drop out of our clinical trials, (v) regulatory approval for our product candidates may not be received or may be delayed, and (vi) our licensees and collaborative partners on whom our success depends may not fulfill their obligations to us. You should also refer to the risks discussed in our other filings with the Securities and Exchange Commission including those contained in our annual report on Form 10-K filed on March 15, 2005. We qualify all our forward-looking statements by these cautionary statements. There may be other factors that may materially affect our forward-looking statements and our future results. Readers should not, therefore, place undue reliance on our forward-looking statements. We do not undertake any obligation and do not intend to update any forward-looking statement.
DOV Pharmaceutical, Inc.CONTACT: Alan Beckhard, Manager, Investor Relations and CorporateCommunications, DOV Pharmaceutical, Inc., +1-201-968-0980
Web site: http://www.dovpharm.com/
