Applied Nanoscience Issues Progress Report on Commercialization Efforts for NanoFense Protective Face Mask

CARLSBAD, CA--(Marketwire - November 12, 2009) -

Applied Nanoscience Inc. (ANI) (PINKSHEETS: APNN), a nanotechnology-based filtration company, today issued a progress report to its investors relating to progress in commercializing the disposable NanoFense™ Protective Face Mask, designed to offer superior protection against a broad spectrum of harmful virus, bacteria and fungi.

The President and CEO of Applied Nanoscience Inc. recently returned from a trip to the Asia Pacific region where he observed that the pilot plant which produces ANI’s proprietary antimicrobial nanoparticle technology (the NanoFense formulation) for application to filter media is secure and can reliably manufacture 1200L/day as planned and previously stated. This formulation will be applied to filter media in order to produce one of the most effective protective masks ever designed.

In concert with commencing production of the “coating” for the NanoFense Protective Face Mask, ANI has established the necessary supplier accounts to ensure consistent and reliable ongoing operation. Paramount to the design of the supply chain and production facility is the protection of the intellectual property developed by the Company. The management team has been working diligently to implement an effective approach to both suppliers and facilities management in order to protect the significant investment that has been made in ANI’s proprietary nanotechnology.

The management team believes the disposable NanoFense Protective Face Mask holds the potential to revolutionize the market for face masks due to its unique ability to not only filter harmful pathogens, but also eradicate pathogens that collect on the mask during use. The technology differs significantly from all other known supposed antimicrobial filtration devices as performance testing is conducted on a NanoFense-coated mask; not on an antimicrobial agent which may then be added to a generic face mask after testing.

Applied Nanoscience believes it is on schedule to supply the formulation for incorporation to filter media and final production by their joint venture partner. The revolutionary disposable NanoFense Protective Face Mask will be made available as soon as possible in an effort to help protect people in some of the most heavily populated parts of the world. Applied Nanoscience Inc. already holds broad patent protection in many of these countries.

About ANI

ANI is a marketer, developer and manufacturer of innovative nanotechnology-based air filtration products specifically targeted to eradicate bacteria, virus and fungi and is the owner of NEFT (Nanoparticle - Enhanced - Filtration - Technology), a broad platform with significant application potential in customer and industrial market segments geared to reducing the transmission of infectious pathogens. For more information on the Company please visit: www.appliednanoscience.com.

Safe Harbor Statement

This release may contain statements that are forward-looking. Such statements are made based upon current expectations that are subject to risk and uncertainty. ANI does not undertake to update forward-looking statements in this news release to reflect actual results of and changes in assumptions or changes and other factors affecting such forward-looking information. The actual future plans and results of the Company could differ significantly from such forward-looking statements.