Dutch researcher Nicole de Voogd has investigated the possibilities for rearing sea sponges in Indonesia. Some of these sponges contain substances of interest to the pharmaceutical industry. As these are increasingly difficult to obtain, there is growing interest in alternative methods of exploitation, such as rearing sponges. For her research, De Voogd described three new species of sponges and examined the interactions of four sponge species with possible spatial competitors. She discovered that as soon as certain sponge species grow over corals, the coral develops necrotic tissue. From this she concluded that the sponges concerned produce their bioactive substances to defeat spatial competitors. This is important, as in an environment without spatial competitors, such as in a sponge culture, a lower concentration of the substances of interest to the pharmaceutical industry might be produced.