American Diabetes Association Release: Higher A1C Levels Linked to Lower Brain Function

ALEXANDRIA, VA--(Marketwire - January 26, 2009) -

Higher average blood glucose (sugar) levels in people with type 2 diabetes are linked to lower cognitive functioning, according to a study published online today in the journal Diabetes Care.

The ongoing Memory in Diabetes (MIND) study, a sub-study of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial, found that higher levels of hemoglobin A1C levels (a measure of the average blood glucose levels over a 2-3 month period) are significantly associated with poorer performance on three cognitive tasks, which require memory, speed and the ability to manage multiple tasks at the same time. A higher A1C level was also associated with a lower score on a test of global cognitive function

Previous studies have shown that people with diabetes are 1.5 times more likely to experience cognitive decline and dementia than people without diabetes. The MIND results suggest diabetes may be associated with mild cognitive impairment.

“Even a mild impairment in cognitive function is of concern for people with type 2 diabetes,” said lead researcher Dr. Tali Cukierman-Yaffe, of the Gertner Institute for Epidemiology & Health Policy Research, Endocrinology Institute at Sheba Medical Center & Sackler School of Medicine at Tel-Aviv University in Israel. However, these results are cross-sectional so it is not yet known whether higher levels of blood sugar increase the risk for cognitive impairment or whether impairment decreases the ability to control blood sugar levels. This will be answered in the ongoing ACCORD-MIND study, in which study patients are followed over time and are tested three times during the trial. One aim of this ACCORD-MIND follow-up is to test the hypothesis that lowering A1C could result in improved cognitive function.

The ACCORD-MIND study was funded by the National Institute on Aging, in collaboration with the ACCORD trial funded by the National Heart, Lung, and Blood Institute (NHLBI). Additional support came from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Eye Institute, and the Centers for Disease Control and Prevention. To obtain a copy of the paper, please contact Dayle Kern at dkern@diabetes.org.

To reach lead researcher Tali Cukierman-Yaffe, email cukierm@mcmaster.ca.

To reach the senior author Lenore J. Launer, email nianews3@mail.nih.gov.

Diabetes Care, published by the American Diabetes Association, is the leading peer-reviewed journal of clinical research into one of the nation’s leading causes of death by disease. Diabetes also is a leading cause of heart disease and stroke, as well as the leading cause of adult blindness, kidney failure, and non-traumatic amputations.

The American Diabetes Association is leading the fight against the deadly consequences of diabetes and fighting for those affected by diabetes. The Association funds research to prevent, cure and manage diabetes; delivers services to hundreds of communities; provides objective and credible information; and gives voice to those denied their rights because of diabetes. Founded in 1940, our mission is to prevent and cure diabetes and to improve the lives of all people affected by diabetes. For more information, please call the American Diabetes Association at 1-800-DIABETES (1-800-342-2383) or visit www.diabetes.org. Information from both these sources is available in English and Spanish.

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