LOS ANGELES--(BUSINESS WIRE)--Abraxis BioScience, Inc. (NASDAQ:ABII), a fully integrated biotechnology company, today announced results from a new ongoing study demonstrating anti-tumor activity for three dosing regimens of nab®-paclitaxel (ABRAXANE® for Injectable Suspension) (paclitaxel protein-bound particles for injectable suspension) (albumin-bound) given in combination with bevacizumab in the first-line treatment of patients with metastatic breast cancer. The overall response rate for patients receiving a combination of weekly nab-paclitaxel (130 mg/m2) with twice weekly bevacizumab (10 mg/kg) was 46 percent. Patients who received a combination of nab-paclitaxel (260 mg/m2) with bevacizumab (10 mg/kg) plus filgrastim administered every two weeks and patients who received nab-paclitaxel (260 mg/m2) with bevacizumab (15 mg/kg) administered every three weeks had overall response rates of 39 percent and 44 percent, respectively. The safety profile was generally consistent with the known safety of nab-paclitaxel and of bevacizumab, although sensory neuropathy was limiting in the weekly nab-paclitaxel dosing arm suggesting a three week on treatment, one week off treatment regimen may be preferable.
