PENZBERG, Germany--(BUSINESS WIRE)--Results from a series of studies presented this week at the 52nd American Society of Hematology Annual Meeting in Orlando, Florida highlight the value of high-throughput sequencing for in-depth characterization of blood cancers, including leukemia and other hematological malignancies. The research studies used the Genome Sequencer FLX and GS Junior Systems from 454 Life Sciences to perform targeted resequencing of known cancer-related genes, such as KRAS, RUNX1, EZH2, and TET2, in order to detect genetic mutations associated with the disease. By sequencing these genomic regions in large numbers of leukemia samples, the researchers were able to successfully identify novel mutations, as well as stratify individuals into unique disease risk subtypes.
