OctoPlus Announces Publication of Phase I Locteron Results in the Journal of Interferon and Cytokine Research

LEIDEN, NETHERLANDS--(Marketwire - March 12, 2008) - OctoPlus N.V. (“OctoPlus” or “the Company”) (Euronext: OCTO), the drug delivery and development company, announces today the publication of results from its Phase I study with Locteron®, its controlled-release formulation of alfa interferon for the treatment of chronic hepatitis C, in the current issue of the Journal of Interferon & Cytokine Research. In the randomised Phase I trial, the administration of Locteron demonstrated bioactivity over a two-week period and resulted in flu-like symptoms that were less frequent, milder and of a shorter duration in a head-to-head comparison with PEG-Intron®, the standard of care used as the control arm in the study.

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