MORRIS PLAINS, N.J., Oct. 22, 2014 (GLOBE NEWSWIRE) -- Immunomedics, Inc., (Nasdaq:IMMU) today announced that Dr. David M. Goldenberg, Chairman, Chief Scientific Officer, and Chief Medical Officer, will present updated results from Phase 2 clinical trials of the Company’s two solid-tumor antibody-drug conjugates (ADCs), isactuzumab govitecan (IMMU-132) and labetuzumab govitecan (IMMU-130), at two upcoming conferences.
At the 5th Annual World ADC Summit in San Diego, CA, Dr. Goldenberg will report “Clinical Performance of Moderately-Toxic ADCs Demonstrates Improved Therapeutic Index in Patients with Diverse Metastatic Solid Cancers,” in the session on “Early Clinical Development Strategies to Demonstrate Patient Benefit,” at 12:00 p.m., Pacific Time, Wednesday, October 29, 2014.
In addition, Dr. Goldenberg will give an invited lecture on “Challenging the dogmas: Clinical efficacy of SN38 conjugated antibodies in solid tumours,” at the 2014 Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain, hosted by the European Organisation for Research and Treatment of Cancer (EORTC), the National Cancer Institute (NCI), and the American Association for Cancer Research (AACR). The oral presentation is scheduled in the “Antibody-Based Therapies (ADC and others)” Plenary Session at 8:20 a.m., Central European Time, Thursday, November 20, 2014.
Cynthia L. Sullivan, President and Chief Executive Officer, commented: “Our founder and chief scientist, Dr. Goldenberg, was invited to present important new Phase 2 trial results with these novel antibody-drug conjugates because our platform technology departs from traditional ADCs by having a high ratio of a moderately cytotoxic drug, SN-38, conjugated to 2 different antibodies that together target most solid cancers. He will report the high therapeutic index of these agents, which is the ability to specifically deliver high and repeated doses with manageable toxicities (mostly neutropenia) in heavily-pretreated patients with metastatic cancers.”
“We believe our ADC platform may represent a paradigm change in this technology, and we are eager to share these encouraging results in very difficult-to-treat cancers. Together, almost 200 patients have been studied with these two agents,” she added.
About Immunomedics
Immunomedics is a clinical-stage biopharmaceutical company developing monoclonal antibody-based products for the targeted treatment of cancer, autoimmune disorders and other serious diseases. Immunomedics’ advanced proprietary technologies allow the Company to create humanized antibodies that can be used either alone in unlabeled or “naked” form, or conjugated with radioactive isotopes, chemotherapeutics, cytokines or toxins. Using these technologies, Immunomedics has built a pipeline of nine clinical-stage product candidates. Immunomedics has an ongoing collaboration with UCB, S.A. (UCB), to whom the Company licensed epratuzumab for the treatment of all non-cancer indications worldwide. UCB expects Phase 3 data in systemic lupus erythematosus in the first half of 2015. Immunomedics is exploring epratuzumab in oncology in collaboration with independent cancer study groups. Immunomedics’ most advanced candidate to which it retains worldwide rights for all indications is 90Y-clivatuzumab tetraxetan. The Company initiated a Phase 3 registration trial in January 2014 in patients with advanced pancreatic cancer and expects topline data in mid-2016. Immunomedics’ portfolio of wholly owned product candidates also includes antibody-drug conjugates (ADCs) that are designed to deliver a specific payload of a chemotherapeutic directly to the tumor while reducing overall toxic effects that are usually found with conventional administration of these chemotherapeutic agents. Immunomedics’ most advanced ADCs are IMMU-132 and IMMU-130, which are in Phase 2 trials for a number of solid tumors and metastatic colorectal cancer, respectively. Immunomedics also has a number of other product candidates that target solid tumors and hematologic malignancies, as well as other diseases, in various stages of clinical and pre-clinical development. These include bispecific antibodies targeting cancers and infectious diseases as T-cell redirecting immunotherapies, as well as bispecific antibodies for next-generation cancer and autoimmune disease therapies, created using its patented DOCK-AND-LOCK® protein conjugation technology. The Company believes that its portfolio of intellectual property, which includes approximately 258 active patents in the United States and more than 400 foreign patents, protects its product candidates and technologies. Immunomedics’ strength in intellectual property has resulted in a top-8 ranking in the Biotechnology industry by the Patent Board for the 2014 fiscal year. For additional information on the Company, please visit its website at www.immunomedics.com. The information on its website does not, however, form a part of this press release.
This release, in addition to historical information, may contain forward-looking statements made pursuant to the Private Securities Litigation Reform Act of 1995. Such statements, including statements regarding clinical trials (including the funding therefor, outcomes, timing or associated costs), out-licensing arrangements (including the timing and amount of contingent payments), forecasts of future operating results, potential collaborations, and capital raising activities, involve significant risks and uncertainties and actual results could differ materially from those expressed or implied herein. Factors that could cause such differences include, but are not limited to, new product development (including clinical trials outcome and regulatory requirements/actions), our dependence on UCB for the further development of epratuzumab for non-cancer indications, risks associated with the outcome of pending litigation, competitive risks to marketed products and availability of required financing and other sources of funds on acceptable terms, if at all, as well as the risks discussed in the Company’s filings with the Securities and Exchange Commission. The Company is not under any obligation, and the Company expressly disclaims any obligation, to update or alter any forward-looking statements, whether as a result of new information, future events or otherwise.
CONTACT: For More Information: Dr. Chau Cheng Senior Director, Investor Relations & Grant Management (973) 605-8200, extension 123 ccheng@immunomedics.com
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