April 14, 2016
By Alex Keown, BioSpace.com Breaking News Staff
CAMBRIDGE, Mass. – Since its founding Seres Therapeutics has been the leading voice in the microbiome space and is blazing a trail with its GI-focused therapies for ailments such as C. diff and ulcerative colitis.
That successful approach to treatment has allowed the company to grow at a quick pace. In 2015 the company saw a growth of more than 200 percent, going from 25 employees to 86, Carlo Tanzi, head of investor relations at Seres told BioSpace . Seres, which is pioneering microbiome therapeutics, has seen explosive growth over the past year and is planning for more. The company plans on expanding its physical footprint in Cambridge, as well as hire on additional staff.
In an exclusive interview with BioSpace, Tanzi and Seres’ Chief Financial Officer Eric Shaff, touted the company’s therapies and provided a blueprint for what is expected to happen at Seres over the coming months and the rest of 2016.
“What we’re seeing in our laboratories every day is exciting stuff,” Shaff said.
Seres was founded by Flagship Ventures and has come out strong since its founding based on the strength of its technology and therapeutics. Shaff said the catalyst behind the company’s growth is how the microbiome could be effective in infectious diseases.
Seres is developing therapies targeting the human microbiome, the bacteria residing in the human gastro-intestinal track, with a particular focus on C diff., ulcerative colitis, as well as some work on immunology and metabolic diseases. Seres’ exciting stuff includes recent positive data for the recurrent C. diff treatment, SER-109 that earned it a breakthrough therapy designation from the U.S. Food and Drug Administration that has the company clearly eying commercializing the product. Additionally, Seres is developing SER-262, a synthetic therapy for primary C. diff, a first-time diagnosis. These oral therapies are considered to be one-shot treatments that will replicate within the GI tract and stave off any future occurrences, Tanzi said. That notion of an effective therapeutic approach is backed up by highly positive Phase Ib clinical data that showed the company’s experimental therapeutics provided a clinical cure for 29 of 30 patients, Shaff said.
“There’s quite an opportunity before us to help patients and I think people will see that more and more as time goes on,” Shaff said.
Last year Seres struck a $1.9 billion deal with Nestle Health Science to further develop treatments for C. diff and inflammatory bowel disease, including ulcerative colitis and Crohn’s disease. That partnership is additional proof of the efficacy of the therapy, Shaff said. SER-109 will be moving into Phase III trials this year.
The success of its research is sparking continued growth at Seres. In November Seres signed a lease to take over 83,000 square feet of space in the old Vertex building in Cambridge to add new laboratory and office space. Shaff said the move was necessary because the company is “busting at the seams in our current facilities.” Shaff said their aspiration is to continue to grow as they focus on “interesting opportunities” to help patients. With the new space, Shaff said he anticipates the company will be hiring new employees.
“We need resources, not just capital resources. We need great people to add to the other great people already here,” Shaff said.
Shaff and Tanzi said the innovative work being done at Seres is something that will attract top employee prospects. Shaff said the fact the company is “doing something new” and innovative, will pique the interest of many perspective job seekers. Tanzi, who joined Seres in December, said that innovative spirit is something that attracted him to the company.
“With the almost tripling of headcount, we’re careful to bring in the right group of people with the right cultural values,” Shaff said. “We’re doing something new and it’s attracting the right people.”
Seres is well financed, having raised $110 million in various financing rounds and then in June 2015, the company went public raising another $140 million. Like many newly public pharma and biotech stocks this year shares of Seres are down from its opening IPO of $51.40. Still, the stock has been a steady performer and is currently trading at $30.49 per share as of this writing. Tanzi said the company is sitting on enough cash reserves to finance operations into 2018.
Shaff said the company lives by a mantra that if you create valuable programs, then financial value will follow.
Although Seres Therapeutics is growing and moving into new facilities, Shaff said it was important for the company to remain in the Cambridge area and be a part of the “Cambridge biotech ecosystem.” With the number of universities and talent pool from other pharma companies, Shaff said the area is an “incredible and unique place to be.”
