Repurpose.AI and Scripps Research Announce a Collaboration to Discover COVID-19 Therapeutics
LA JOLLA, Calif., June 23, 2020 /PRNewswire/ -- Repurpose.AI, an AI drug discovery company, today announced a collaboration with Scripps Research to develop COVID-19 therapeutics. Scripps Research is ranked the most influential institution in the world for innovation by Nature Index.
The partnership will leverage Repurpose.AI's ActivPred AI Drug Discovery Platform, an unbiased drug, target, and disease agnostic digital chemistry engine, to discover drug candidates to treat COVID-19. Previously, the company has successfully utilized the platform to discover REP-001, REP-002, and REP-003 – three Phase II/III ready small molecule assets for the treatment of gastric, neurological, and weight disorders, respectively.
Repurpose.AI, a Nex Cubed digital health portfolio company, has harnessed the predictive prowess of artificial intelligence and machine learning with its ActivPred AI Drug Discovery Platform to discover drugs that may be repurposed to serve as therapeutics to treat patients suffering from COVID-19. The drugs that Repurpose.AI discovers for COVID-19 can enter clinical trials in as little as several months.
Repurpose.AI's Drug Library is comprised of approximately 4,000 drug compounds that have been approved for commercial use by the U.S. FDA, or similar agencies, and 20,000+ drug compounds that are known to have successfully navigated a Phase I (human safety) clinical trial. All drugs have a full pre-clinical program, an existing or legacy supply chain, and are known to be safe and well-tolerated in humans.
Scripps Research scientists together with Calibr, its drug development division, will leverage its COVID-19 screening models and commitment to drug repurposing as part of the partnership. Calibr previously established the ReFRAME collection, the world's leading collection of known drugs, comprising over 14,000 compounds that have been approved by the FDA for other diseases or have been extensively tested for human safety, which it is bringing to bear on the current pandemic. The collaborative work with Repurpose.AI will augment this effort by characterizing compounds not identified to date using conventional repurposed drug screening approaches.
Dr. George Nicola, Ph.D., MBA, Founder and CTO at Repurpose.AI commented, "We have created a COVID-19 specific version of our ActivPred AI Drug Discovery Platform that focuses exclusively on identifying safe and effective, non-obvious therapeutics with activity against biological targets related to COVID-19 infection. Repurpose.AI's Digital Chemistry Drug Discovery Platform leverages artificial intelligence based on fundamental chemistry to discover drugs active against COVID-19 that cannot be resolved with traditional high throughput screening approaches. At a time when tens of thousands of new COVID-19 infections occur globally each day, a partnership with Scripps Research will enable us to accelerate the pace at which these discoveries are developed."
Dr. Arnab Chatterjee, Ph.D., VP of Medicinal Chemistry for Calibr at Scripps Research commented, "We are enthusiastic to redouble our efforts in drug repurposing by leveraging Repurpose.AI's platform, which we see as highly complementary to our screening efforts to date."
Dr. Daniel Haders II, Ph.D., Executive Chairman at Repurpose.AI added, "We could not be more excited about our partnership with Scripps Research and Calibr. Like Repurpose.AI, Calibr is committed to ending the scourge of the global COVID-19 pandemic. Our goal is to move therapeutics from the computer to the clinic in a fraction of the time typically required to discover and bring new drugs to market and alleviate the suffering of patients afflicted by COVID-19. Creating therapeutics to treat COVID-19 also allows the global community to go back to work and for children to go back to school. Repurpose.AI and Calibr are committed to doing our part to ensure that happens sooner rather than later."
About The Scripps Research Institute
About Nex Cubed
View original content to download multimedia:http://www.prnewswire.com/news-releases/repurposeai-and-scripps-research-announce-a-collaboration-to-discover-covid-19-therapeutics-301082166.html