MEI Pharma Interim Data Review Supports Continuation of Clinical Study Evaluating ME-344 in Patients with Breast Cancer
Interim data further support potential of ME-344 to reverse resistance to antiangiogenic therapy
SAN DIEGO, Feb. 13, 2018 /PRNewswire/ -- MEI Pharma, Inc. (NASDAQ: MEIP), an oncology company focused on the clinical development of novel therapies for cancer, today announced that a planned interim review of data supports continuation of its multicenter, investigator sponsored, study evaluating ME-344, a novel mitochondrial inhibitor, in patients with HER2-negative breast cancer. The interim study data show that ME-344 was generally well-tolerated and, consistent with previous preclinical data, demonstrate the potential to reverse resistance to antiangiogenic therapy. Based on the interim results, it was determined that completion of enrollment of the clinical study of ME-344 in combination with bevacizumab (marketed as Avastin®) is warranted.
"The interim data are very encouraging and I look forward to an opportunity to present the results at a medical meeting later this year," stated the study principal investigator, Miguel Quintela-Fandino, M.D., Ph.D., Director of the Clinical Research Program, Centro Nacional De Investigaciones Oncologicas, Madrid, Spain.
Dr. Quintela-Fandino continued: "These preliminary data are consistent with our previously published preclinical studies and it is our hope that the data from the current clinical study will help advance our understanding of the escape pathways utilized by tumors against antiangiogenic agents. The therapeutic opportunity that is available to exploit the adaptive mechanisms of tumors via mitochondrial inhibition is quite novel and I am very excited to continue the trial and further explore the promising utility of ME-344 in combination with antiangiogenic therapeutics."
Inhibition of mitochondrial adenosine triphosphate (ATP) with drug candidates such as ME-344 may have significant potential in combination with antiangiogenic agents. Antiangiogenics are widely used biologic agents in oncology, but acquired resistance to antiangiogenics is a major problem in cancer therapeutics. Antiangiogenics reduce the rate of glycolysis as a mechanism to block tumor growth, however sustained tumor growth may be achieved via a shift to an alternative metabolic energy source such as mitochondrial ATP*. In such cases of tumor plasticity in the presence of treatment with antiangiogenics, targeting the alternative metabolic source would open an important therapeutic opportunity.
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Company Codes: NASDAQ-SMALL:MEIP