Aruvant Announces Oral Presentation at 15th Annual Sickle Cell Disease Research & Educational Symposium & 44th National Sickle Cell Disease Scientific Meeting
NEW YORK and BASEL, Switzerland, May 27, 2021 /PRNewswire/ -- Aruvant Sciences ("Aruvant"), a private company focused on developing gene therapies for rare diseases, today announced that data on ARU-1801, a potentially curative lentiviral gene therapy for sickle cell disease (SCD), will be delivered in an oral presentation at the 15th Annual Sickle Cell Disease Research & Educational Symposium & 44th National Sickle Cell Disease Scientific Meeting. Dr. Monika Asnani, professor of family medicine & epidemiology at the Caribbean Institute for Health Research, will present data from the ARU-1801 Phase 1/2 MOMENTUM clinical trial during the meeting which will take place virtually from May 27 to May 30, 2021.
ARU-1801 is a lentiviral gene therapy that is administered once and designed to address the limitations of current curative treatment options, such as low donor availability and toxicity from conditioning chemotherapy. Dr. Asnani's oral presentation will review early safety and efficacy results from the first three patients in the ongoing MOMENTUM study of ARU-1801 with reduced intensity conditioning (RIC) in patients with SCD.
"Dr. Asnani will be presenting preliminary data that shows the promise of ARU-1801 as a potentially curative gene therapy that can be delivered without exposing patients to high intensity chemotherapy," said Will Chou, M.D., chief executive officer of Aruvant. "Long-term results from the first two patients showed between 85 and 93 percent reduction in the number of vaso-occlusive events (VOEs) and complete resolution of VOEs at 12 months for the third patient, the first participant treated with a newer manufacturing process used to improve efficacy. These results indicate that it may be possible to successfully treat individuals with SCD using only reduced intensity conditioning with ARU-1801."
Treatment with ARU-1801 has shown meaningful improvement in clinical outcomes. In the 24 months before treatment with ARU-1801, patients had 12 to 41 VOEs and were hospitalized for one to seven of those VOEs. In the 24 months after treatment, patients one and two have seen 93% and 85% reductions in the number of VOEs, respectively and patient three has had no VOEs through 12 months of follow-up, a 100% reduction. The corresponding total days in hospital associated with those VOEs had an average reduction of 93.8 percent. These results are an encouraging sign of the therapeutic benefit of ARU-1801 with RIC for patients with SCD.
Presentation Title: Early Results from a Phase 1/2 Study of ARU-1801 Gene Therapy for Sickle Cell Disease
The MOMENTUM Study
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SOURCE Aruvant Sciences