Leuven, March 17 2016 – ThromboGenics NV (Euronext Brussels: THR), an integrated biopharmaceutical company focused on developing and commercializing innovative treatments for diabetic eye disease, today announces that it has signed a global and exclusive license agreement with Galapagos NV (Euronext & NASDAQ: GLPG) to develop and commercialize integrin antagonists for the treatment of diabetic eye disease. The license agreement will give ThromboGenics access to a collection of integrin antagonists developed by Galapagos.
Research to-date suggests that integrin antagonists could play an important role in the treatment of back of the eye diseases, including diabetic eye diseases. Initially, ThromboGenics intends to further explore and characterize the integrin antagonists that it has in-licensed from Galapagos using a number of well validated preclinical models of diabetic eye disease. ThromboGenics believes that by gaining access to these molecules, it has the potential to develop a novel small molecule integrin antagonist which could be used to treat a broad range of patients with diabetic retinopathy, with or without diabetic macular edema. ThromboGenics has designated the most advanced of these integrin antagonist drug candidates as THR-687.
According to the International Diabetes Federation, there are about 415 million people with diabetes worldwide and this number is expected to double over the next 20 years. One in three diabetics will develop diabetic retinopathy at some stage in his or her lifetime. As a result, the market for new treatments for diabetic retinopathy is expected to be one of the fastest growing segments of the ophthalmic medicines market. Over the period to 2023 this market segment is forecast to grow at over 16% per annum from $1.6 billion to $4.2 billion, which is about double the growth rate of the overall ophthalmology market.
Dr Patrik De Haes, CEO of ThromboGenics, comments: “We are pleased to have signed this in-licensing deal with Galapagos which will provide us with access to a collection of integrin antagonists, an exciting class of drugs being developed for back of the eye disease. This deal is a further important step in our goal to build one of the industry’s leading pipelines targeting diabetic eye disease based on novel disease modifying compounds. Diabetic eye disease is the fastest growing segment of the overall ophthalmology market, and the number of patients needing improved treatment options for both diabetic retinopathy and diabetic macular edema is expected to grow significantly over the next decade.”
Onno van de Stolpe, CEO of Galapagos, said: “We believe that ThromboGenics is a great partner for this collection of integrin antagonists that we have developed. ThromboGenics has shown thorough understanding of the back of the eye disease in the pre-clinical models that they have developed, in order to assess these potential drug candidates for both diabetic retinopathy and diabetic macular edema. We are looking forward to watching their progress.”
Under the terms of the agreement, ThromboGenics will pay a €1 million upfront technology-transfer payment to Galapagos. Galapagos will also be entitled to receive certain development and commercial milestone payments plus royalties based on any future annual net sales of products that originated from its library of integrin antagonists.
ThromboGenics
Wouter Piepers,
Global Head of Corporate Communications & IR
+32 16 75 13 10 / +32 478 33 56 32
wouter.piepers@thrombogenics.com
Citigate Dewe Rogerson
David Dible/ Sylvie Berrebi
+44 20 7282 2867
David.dible@citigatedr.co.uk
Sylvie.berrebi@citigatedr.co.uk
About ThromboGenics
ThromboGenics is an integrated biopharmaceutical company focused on developing and commercializing innovative treatments for back of the eye disease, with a focus on diabetic eye disease. ThromboGenics is conducting the CIRCLE study, a Phase II clinical trial to assess ocriplasmin (THR-409) as a potential treatment for diabetic retinopathy In addition the Company is evaluating several other disease modifying drug candidates that could potentially deliver a number of next generation treatments for diabetic eye disease. ThromboGenics pioneered the new drug category of pharmacological vitreolysis with JETREA® (ocriplasmin) which is now approved for the treatment of vitreomacular traction in over 54 countries worldwide. In the US, ThromboGenics is commercializing JETREA® via its subsidiary ThromboGenics, Inc. Alcon, a division of Novartis, commercializes JETREA® outside the United States ThromboGenics is headquartered in Leuven, Belgium, and is listed on the NYSE Euronext Brussels exchange under the symbol THR. More information is available at www.thrombogenics.com.
About Galapagos
Galapagos (Euronext & NASDAQ: GLPG) is a clinical-stage biotechnology company specialized in the discovery and development of small molecule medicines with novel modes of action. Its pipeline comprises three Phase 2, three Phase 1, five pre-clinical, and 20 discovery studies in cystic fibrosis, inflammation, fibrosis, osteoarthritis and other indications. Galapagos has discovered and developed filgotinib: in collaboration with Gilead it aims to bring this JAK1-selective inhibitor for inflammatory indications to patients all over the world. Galapagos is focused on the development and commercialization of novel medicines that will improve people’s lives. The Galapagos group, including fee-for-service subsidiary Fidelta, has approximately 440 employees, operating from its Mechelen, Belgium headquarters and facilities in The Netherlands, France, and Croatia. More information at www.glpg.com.
