CAMBRIDGE, Mass & STRASBOURG, France--(BUSINESS WIRE)--Sirtris Pharmaceuticals and the University Louis Pasteur, Strasbourg announced that in an article published today in Cell, “Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1a.” Lagouge et al., Cell. 2006; 127: 1–14, SIRT1 was shown for the first time in a human population to accelerate metabolic rate.