Shire Pharmaceuticals Appoints New General Manager for Spain

BASINGSTOKE, England and MADRID, Spain - 10 September, 2007 - Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ), the global Specialty biopharmaceutical company, announced today the appointment of Steve Howson as its new VP & General Manager for its Spanish operations, following the retirement of Jose Antonio Senz de Broto. Steve will take up his new appointment with effect from 1 September, with a handover period with Jose Antonio through to the end of this year.

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