NEWTON, Mass.--(BUSINESS WIRE)--Pro-Pharmaceuticals, Inc. (Amex:PRW), a developer of first-in-class carbohydrate therapeutic compounds, today announced that Tampa General Hospital began dosing patients in a Phase II, first line, biliary cancer trial. The Phase II trial is an open-label, multi-center trial of DAVANAT® with 5-Fluorouracil (5-FU) to treat patients with advanced bile duct and gall bladder cancer.