NEW YORK--(BUSINESS WIRE)--Pfizer Inc said today that it is disappointed by the Canadian Federal Court’s decision declaring invalid its patent covering amlodipine besylate, the active ingredient in Norvasc®, and that the company will appeal the decision to the Federal Court of Appeal of Canada. Pfizer’s amlodipine besylate patent - Canadian Patent No. 1,321,393 - expires in 2010. The civil action was brought by Ratiopharm.