MELVILLE, N.Y.--(BUSINESS WIRE)--Jan. 11, 2006--OSI Pharmaceuticals, Inc. (NASDAQ:OSIP) today announced fourth quarter and year-end net U.S. sales for its flagship product, Tarceva(R) (erlotinib). Net U.S. sales for Tarceva increased 15 percent over the third quarter to $83.9 million for the fourth quarter ended December 31, 2005. Total U.S. net sales of Tarceva for 2005, its launch year, were $274.9 million. U.S. net sales of Tarceva as recorded by Genentech, Inc., OSI’s U.S. collaborator for Tarceva included an adjustment of approximately $3 million in the fourth quarter relating to government rebates and allowances. Number of days of inventory levels at wholesalers was consistent with the prior quarter. The announcement follows the release of Tarceva U.S. sales data reported by Genentech in their year-end press release and conference call.