Nutlin-Induced Apoptosis Analyzed Using Roche’s xCELLigence System and RealTime ready Focus Panels

PENZBERG, Germany--(BUSINESS WIRE)--The p53 tumor suppressor, a transcription factor that activates or inhibits hundreds of genes, either directly or indirectly, triggers a variety of cellular effects and plays a central role in the cellular defense against cancer. One of the main approaches for pharmacological intervention is to activate wild-type p53 in cancer cells by blocking MDM2 from binding to p53. Scientists have recently identified nutlins - small molecules inhibiting p53/MDM2 interaction – which represent valuable tools for studying p53 regulation and facilitating the development of cancer therapies.

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