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Blood transfusions are supposed to save lives. Doctors give transfusions to severely ill or injured people with the expectation that their conditions will improve. In fact, transfusions do not always help and can even make things worse. When red blood cells are stored, their ability to deliver oxygen decreases. This can cause tissue hypoxia in patients who receive blood transfusions, resulting in severe complications. In a study that appears in the Proceedings of the National Academy of Sciences, Jonathan Stamler of Case Western Reserve University in Cleveland and his colleagues show that adding nitric oxide to stored red blood cells improves oxygen delivery.
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