CARLSBAD, Calif., April 26 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq:ISIS - News) announced today that it will conduct the second of its series of four conference calls focused on the drugs in Isis’ development pipeline. The second call of the series will focus on Isis’ metabolic franchise and will be held on Wednesday, April 28, 2010 at 12:00 p.m. ET. This call will be archived for a limited time on Isis’ Web site.