CAMBRIDGE, Mass.--(BUSINESS WIRE)--Idera Pharmaceuticals, Inc. (Nasdaq: IDRA) today announced results from its single-dose, dose-escalation Phase 1 clinical trial evaluating the safety and mechanism of action of IMO-3100, its lead Toll-like Receptor (TLR) 7 and TLR9 antagonist drug candidate for the treatment of autoimmune and inflammatory diseases. In the trial, IMO-3100 was well tolerated at all dose levels evaluated in the 30 healthy subjects that received IMO-3100, and target engagement of TLR7 and TLR9 was observed through inhibition of TLR7- and TLR9-mediated immune responses. The presentation entitled “Safety and Pharmacodynamics of IMO-3100, a Novel Toll-like Receptor Antagonist for Autoimmune and Inflammatory Diseases, in a Rising Single-Dose Phase 1 Clinical Trial” was made today at the 6th Annual Meeting of the Oligonucleotide Therapeutic Society being held in Dana Point, California.
