HPS Analysis Finds No Association Between KIF6 Genotype and Vascular Risk or Statin Response, Oxford University Study

The heart.org -- Oxford, UK - An analysis of the Heart Protection Study (HPS) casts further doubt on any association between a variant in KIF6, a gene that encodes the kinesinlike protein-6, and vascular risk, with investigators reporting that the KIF6 genotype had no impact on the risk of major vascular events, major coronary events, revascularizations, or stroke [1]. In addition, carriers and noncarriers of the genetic polymorphism had similar reductions in the risk of major vascular events when treated with simvastatin 40 mg.