DURECT Corporation Presenting At The Sixteenth Annual CIBC Healthcare Conference

CUPERTINO, Calif., Nov. 4 /PRNewswire-FirstCall/ -- DURECT Corporation announced today that it will present at the Sixteenth Annual CIBC Healthcare Conference. The conference is being held at The Waldorf-Astoria Hotel in New York, New York. Dr. James E. Brown, President and Chief Executive Officer, will be presenting at the conference on Tuesday, November 8th, 2005 at 10:30 a.m. EST.

(Logo: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO )

A live audio webcast of the presentation will be available by accessing DURECT’s homepage at http://www.durect.com and clicking “Investor Relations.”

About DURECT Corporation

DURECT Corporation is an emerging specialty pharmaceutical company focused on the development of pharmaceutical systems based on its proprietary drug delivery platform technologies that treat chronic debilitating diseases and enable biotechnology products. These platform technologies include the SABER(TM) Delivery System (a patented and versatile depot injectable useful for protein and small molecule delivery), the ORADUR(TM) sustained release oral gel-cap technology (an oral sustained release technology with several potential abuse deterrent properties), the DURIN(TM) Biodegradable Implant (drug-loaded implant system), the TRANSDUR(TM) transdermal technology and the MICRODUR(TM) Biodegradable Microparticulates (microspheres injectable system). DURECT also collaborates with pharmaceutical companies to develop and commercialize proprietary and enhanced pharmaceutical products based on its technologies. DURECT has five disclosed on-going development programs of which four are in collaboration with pharmaceutical partners. Additional information about DURECT is available at www.durect.com.

NOTE: SABER(TM), ORADUR(TM), DURIN(TM), TRANSDUR(TM) and MICRODUR(TM) are trademarks of DURECT Corporation. Other referenced trademarks belong to their respective owners.

DURECT Forward-Looking Statement

The statements in this press release regarding DURECT’s products in development, product development plans are forward-looking statements involving risks and uncertainties that can cause actual results to differ materially from those in such forward-looking statements. Potential risks and uncertainties include, but are not limited to, DURECT’s ability to complete the design, development, and manufacturing process development of the product candidate, obtain product and manufacturing approvals from regulatory agencies and manufacture and commercialize the product candidate, as well as marketplace acceptance of the product candidate. Further information regarding these and other risks is included in DURECT’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2005 filed with the SEC on October 13, 2005 under the heading “Factors that may affect future results.”

Photo: NewsCom: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGOAP Archive: http://photoarchive.ap.orgPRN Photo Desk, photodesk@prnewswire.comDURECT Corporation

CONTACT: Schond L. Greenway, Executive Director, Investor Relations andStrategic Planning of DURECT Corporation, +1-408-777-1417

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