On August 15, 2019, the global leading peptide supplier Creative Peptides announces to release a product line of photo cross linkers for researchers who are engaged with custom labeling, peptide bioconjugation as well as peptide modification.
Shirley, New York - On August 15, 2019, the global leading peptide supplier Creative Peptides announces to release a product line of photo cross linkers for researchers who are engaged with custom labeling, peptide bioconjugation as well as peptide modification.
Cross-linking is defined as the process of chemically binding two or more molecules together via a covalent bond. In most cases, cross linkers include an end that is reactive with specific functional groups located on proteins or other molecules, such as primary amines and sulfhydryl groups. The chemical groups used for cross-linking are diverse, and proteins and polypeptides are often used as targets for coupling in cross-linking studies.
“The benefits of photo cross linkers are wide-ranged. In medicinal chemistry and biology, they often serve as invaluable tools for identifying drug targets and off-targets, elucidating interactions of biomolecules or probing the binding sites,” says Dr. Robert Martinez, spokesperson from Creative Peptides. “But conventional approaches of photo-cross-linking used to identify transient interactions are still problematic due to their cross-linked bait proteins. Against such backdrop, genetically encoded protein photo-cross-linkers are good choices, which present a powerful strategy to capture protein–protein interactions.”
In addition, such photo cross linkers also show great potentials in profiling protein interaction networks, mapping binding interfaces, and probing dynamic changes in both physiological and pathological settings. “Nevertheless, no matter how successful they are, some technical challenges still remain. Scientists need to solve the problem of simultaneously capturing the promiscuous binding partners while at the same time, directly identifying the interaction interfaces.”
Cross-linking is a good strategy to stabilize weak interactions to help detect low abundance proteins in interaction proteomics studies. Besides, photo-reactive cross linkers are also widely used for nonspecific bioconjugation. The conjugation between peptides and drugs holds a promising stance in targeted therapy, which not only helps to deliver therapeutic agents but also enhances the therapeutic potential of drugs, to some degree.
To know more about the photo cross linkers, custom conjugation and peptide modification services at Creative Peptides, please visit:https://www.creative-peptides.
About Creative Peptides
With over a dozen of years’ experience in peptide manufacturing and synthesis, Creative Peptides has now gained a fame not only in supplying API peptides, cosmetic peptides, catalog peptides, cell penetrating peptides and alike, but also in providing a widely encompassing integrated peptide service, including custom peptide synthesis, stapled peptide synthesis, GMP manufacturing, peptide drug discovery as well as, etc.
