As the leading expert in small molecular and antibody engineering, BOC Sciences announced to add Antibody Drug Conjugates to its service range on December 18, 2017.
As the leading expert in small molecular and antibody engineering, BOC Sciences announced to add Antibody Drug Conjugates to its service range on December 18, 2017. This move would greatly facilitate scientists’ efforts in drug development, according to the spokesperson of BOC Sciences.
Composed of an antibody linked to a biologically active cytotoxic payload or drug, Antibody Drug Conjugates (ADCs) are a very important class of highly potent drugs designed as a targeted therapy to treat various cancers. Over the past few decades, Antibody Drug Conjugates have nearly revolutionized the field of cancer chemotherapy.
“Unlike the conventional chemotherapy, which will also damage healthy tissues during dose escalation, Antibody Drug Conjugates only target and kill cancer cells and thus sparing healthy cells,” said the Chief Scientist of BOC Sciences’ ADCs team. “Having the advantages of high specificity and being only tumor-specific, Antibody Drug Conjugates have been widely recognized as an effective targeted therapy.”
Owing to its rich experience, BOC Sciences is capable of providing the most comprehensive services ranging from conjugation to characterization of Antibody-Drug Conjugates, and fully supports the development of ADC products for all phases of drug development from discovery to GMP manufacturing.
About Composition of Antibody Drug Conjugates
An ideal antibody drug conjugate should have the following three components:
A highly selective monoclonal antibody for a tumor-associated antigen that has restricted or no expression on healthy cells;
A potent cytotoxic small molecule drug designed to induce target cell death after being internalized in the tumor cell and released;
A linker that is stable in circulation, but releases the cytotoxic agent in target cells.
About BOC Sciences
With inhibitors, natural compounds, metabolites and impurities as its featured products, BOC Sciences also provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery, which includes custom synthesis of chemicals that are not in stock, isotope labeling service, chiral synthesis and resolution, as well as analytical services, etc.
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