BioMarin Pharmaceutical Inc. To Host Research And Development Day On Tuesday, December 6

NOVATO, Calif., Nov. 22 /PRNewswire-FirstCall/ -- BioMarin Pharmaceutical Inc. announced today that it will host a “Research and Development Day” to discuss the company’s marketed products and product opportunities, including 6R-BH4 for the treatment of phenylketonuria (PKU) and cardiovascular disease. Presentations will be made by BioMarin senior management and medical thought leaders. The event, which will be held at the Four Seasons Hotel in New York City, New York, will take place on Tuesday, December 6, 2005 from 7:30 a.m. to 10:30 a.m. ET.

To register to attend, please contact Lauren Glaser of The Trout Group at 415.392.3310 or at lglaser@troutgroup.com. Those who are unable to attend can access a live audio webcast of the event via the investor section of the BioMarin website, www.BMRN.com. A replay of will be available on the site at least two weeks after the event.

About BioMarin

BioMarin develops and commercializes innovative biopharmaceuticals for serious diseases and medical conditions. The company’s product portfolio is comprised of three approved products and multiple clinical and preclinical product candidates. Approved products include Naglazyme(TM) (galsulfase) for mucopolysaccharidosis VI (MPS VI), a product wholly developed and commercialized by BioMarin, Aldurazyme(R) (laronidase) for mucopolysaccharidosis I (MPS I), and Orapred(R) (prednisolone sodium phosphate oral solution) for inflammatory conditions. Investigational product candidates include Phenoptin(TM) (sapropterin dihydrochloride), a Phase 3 product candidate for the treatment of phenylketonuria (PKU). For additional information, please visit www.BMRN.com. Information on BioMarin’s website is not incorporated by reference into this press release.

Forward-Looking Statement

This press release contains forward-looking statements about the business prospects of BioMarin Pharmaceutical Inc., including, without limitation, statements about: continued current and proposed future development of Phenoptin and 6R-BH4. These forward-looking statements are predictions and involve risks and uncertainties such that actual results may differ materially from these statements. These risks and uncertainties include, among others: results and timing of current and planned preclinical studies and clinical trials, including the Phase 3 clinical trial of Phenoptin; the content and timing of decisions by the U.S. Food and Drug Administration, the European Commission and other regulatory authorities concerning Phenoptin and BH4; and those factors detailed in BioMarin’s filings with the Securities and Exchange Commission, including, without limitation, the factors contained under the caption “Factors That May Affect Future Results” in BioMarin’s 2004 Annual Report on Form 10-K, as amended, and the factors contained in BioMarin’s reports on Form 10-Q and Form 8-K. Stockholders are urged not to place undue reliance on forward-looking statements, which speak only as of the date hereof. BioMarin is under no obligation, and expressly disclaims any obligation to update or alter any forward-looking statement, whether as a result of new information, future events or otherwise.

NOTE: Aldurazyme(R) is a registered trademark of BioMarin/Genzyme LLC.

Orapred(R) is a registered trademark of Medicis Pediatrics, Inc. and is used under license. Contacts: Investors Media Joshua A. Grass Susan Ferris BioMarin Pharmaceutical Inc. BioMarin Pharmaceutical Inc. (415) 506-6777 (415) 506-6701

BioMarin Pharmaceutical Inc.

CONTACT: investors, Joshua A. Grass, +1-415-506-6777, or media, SusanFerris, +1-415-506-6701, both of BioMarin Pharmaceutical Inc.

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