Study Demonstrates Safety and Tolerability and its Potential Impact on Metabolism to Elicit Anti-Cancer Response in Brain Cancer
| FRAMINGHAM, Mass., June 1, 2020 /PRNewswire/ -- Berg, a clinical-stage biotech company that uses Artificial Intelligence (AI) to research diseases and develop innovative treatments, today announced results from a Phase 1 clinical study of its investigational drug, BPM 31510 (novel ubidecarenone formulation) in glioblastoma (GBM). The study, presented at the 2020 American Society of Clinical Oncology Annual Meeting (ASCO), highlights safety, tolerability and the impact of BPM 31510-IV influence on metabolism in patients, supporting planned Phase 2 clinical development.
“At BERG, we understand the toll cancer takes not only on a patient, but also their loved ones, and we want to lead in the battle to fight the disease,” said Dr. Niven R. Narain, BERG Co-founder, President and Chief Executive Officer. “BPM 31510 is a unique therapeutic modality targeting cell metabolism that is consistent with our proprietary Interrogative Biology® platform. We are excited at the opportunities the findings will have in refining clinical development among multiple cancer indications, especially in brain cancers.” GBM is a destructive type of brain cancer often acknowledged for its steep morbidity and mortality rates. There are few effective treatment options available in the marketplace, thus substantiating the urgent need for novel therapeutic approaches to improve outcomes for this disease. BPM 31510 is a unique therapeutic modality which specifically targets cell metabolism and shifts the cancer’s glycolytic dependency toward mitochondrial oxidative phosphorylation. When applied, it induces oxidative stress and causes cell death, specifically of cancer cells. BPM 31510 serves as particularly relevant indication for GBM’s glycolytic dependency. The study was led by Seema Nagpal, M.D. Clinical Associated Professor of Neurology & Neurological Sciences, and Lawrence Recht, M.D., Professor of Neurology & Neurological Sciences, both of Stanford University School of Medicine, with other Stanford Medicine researchers and in collaboration with BERG. Details of the BERG presentation: In its commitment to serve patients afflicted with cancer, BERG has collaborated on other projects with leading institutions, like MD Anderson Cancer Institute (clinical trials) and Harvard/BIDMC (Project Survival), among others. About BERG For additional information, please visit http://www.berghealth.com. Media Contact:
SOURCE BERG Health |
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