Zymo Research Receives SBIR-STTR Grant From the NIH
Epigenetic Markers and Sustained Cytoprotection for Stroke Treatment
IRVINE, Calif., Dec. 19, 2017 /PRNewswire/ -- Zymo Research has been awarded a Phase I Small Business Technology Transfer (STTR) grant from the National Institutes of Health. The STTR Program requires small businesses to collaborate with a research institution. The program's goals according to their website are as follows:
According to the Centers for Disease Control and Prevention, strokes kill about 140,000 Americans each year and are the leading cause of serious long-term disability. Zymo Research will use the $225,000 (USD) grant to discover the epigenetics signatures that indicate sustained cytoprotection and develop an epigenetics panel that can be used to predict cytoprotection. Zymo Research will be working with researchers at The University of Texas Health Science Center at Houston (UTHealth) who recently demonstrated that a Xenon-liposome treatment, administered post-stroke, resulted in the activation of endogenous brain protection following an ischemic stroke (blood clot) and subarachnoid hemorrhage, which is typically caused from a head injury or a cerebral aneurysm.
Dr. Keith Booher, Services Projects Manager at Zymo Research stated, "Stroke injury, such as paralysis or speech problems, occurs through pathologic changes that can lead to long-term neurologic dysfunction of the patient. Our goal is to identify various reliable epigenetic biomarkers that will help determine the optimum frequency and duration of Xenon-containing liposome delivery."
Xenon has been found to have neuroprotective properties; however, a suitable administration strategy has yet to be developed. Zymo Research, a pioneer in the field of epigenetics, and UTHealth, who holds the patents for the use of Xenon-containing liposomes for the prevention and treatment of stroke, will collaborate to translate this technology into a clinical product that can be used to decrease the debilitating effects on stroke patients.
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