Leica Microsystems Release: Explore Life's True Nature With Super-Resolution And Nanoscopy

Published: Nov 03, 2016

Leica Microsystems paves the way to access imaging beyond the diffraction limit with HyVolution 2 and the Leica TCS SP8 STED ONE

Mannheim, Germany. With the Super-Resolution Technology HyVolution 2 and the Leica TCS SP8 STED ONE Nanoscope, Leica Microsystems expands its product portfolio for light microscopy having resolution beyond the diffraction limit. With these technologies, scientists in neurobiology, cancer research, and immunology can visualize molecular interactions and structures in living cells in order to understand life's true nature. With HyVolution 2 and the Leica TCS SP8 STED ONE, Leica Microsystems offers researchers and imaging facilities attractive solutions for getting started using super-resolution and nanoscopy.

"During the last 20 years, super-resolution and nanoscopy have revolutionized research on functional interactions inside cells at the molecular level. This is also reflected in the Nobel Prize for Chemistry of 2014", says Markus Lusser, President of Leica Microsystems. "These technologies are well on their way to establishing themselves as standard fluorescence methods for fundamental biomedical research. On the basis of our proven TCS SP8 platform, we now offer a complete portfolio for confocal imaging beyond the diffraction limit: from HyVolution 2 for super resolution at the touch of a button - to the TCS SP8 STED ONE for getting started in 3D-Nanoscopy - to our successful TCS STED 3X for multi-color STED imaging over the full spectral range. Leica Microsystems is the only company which has more than 12 years of experience in developing commercial imaging systems that can resolve beyond the diffraction limit."

With the HyVolution 2 Super-Resolution Technology allowing resolution down to 140 nanometers, processes and structures can be resolved in several colors simultaneously with high acquisition speed and high signal-to-noise ratio. HyVolution 2, which is available for all existing and new Leica TCS SP8 systems, combines highly sensitive Leica HyD Hybrid Detectors, the Leica TCS SP8 spectral detection system, seamlessly integrated Huygens deconvolution software, and high speed graphic processors.

The Leica TCS SP8 STED ONE Nanoscope achieves a resolution down to 30 nanometers. The system reveals morphology and dynamics inside cells at the molecular level - in 2D and 3D - and allows the co-localization of molecules to be reliably quantified. For different applications, the STED ONE is available either with a 592 or 660 STED laser. The spectral detection system combines sensitivity with the Leica HyDs and freely selectable excitation wavelength of the white light laser to make the Leica TCS SP8 STED ONE a flexible imaging system.

More information on HyVolution 2: http://www.leica-microsystems.com/products/confocal-microscopes/details/product/hyvolution-2/

More information on Leica TCS SP8 STED ONE: http://www.leica-microsystems.com/products/confocal-microscopes/details/product/leica-tcs-sp8-sted-one/

On Science Lab, the knowledge portal around microscopy by Leica Microsystems, readers will find articles, interviews, and webinars on super-resolution and nanoscopy: http://www.leica-microsystems.com/science-lab/topics/super-resolution/

About Leica Microsystems

Leica Microsystems develops and manufactures microscopes and scientific instruments for the analysis of microstructures and nanostructures. Ever since the company started as a family business in the nineteenth century, its instruments have been widely recognized for their optical precision and innovative technology. It is one of the market leaders in compound and stereo microscopy, digital microscopy, confocal laser scanning microscopy with related imaging systems, electron microscopy sample preparation, and surgical microscopes.

Leica Microsystems has seven major plants and product development sites around the world. The company is represented in over 100 countries, has sales and service organizations in 20 countries, and an international network of distribution partners. Its headquarters are located in Wetzlar, Germany.

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