Hoag to Participate in Groundbreaking Study Aiming to Help Prevent Memory Loss Due to Alzheimer's Disease

 

NEWPORT BEACH, Calif., June 3, 2021 /PRNewswire/ -- Hoag's Pickup Family Neurosciences Institute has started recruiting volunteers for a study testing an investigational treatment that aims to help prevent the earliest stages of memory loss due to Alzheimer's disease.

Funded by the National Institutes of Health (NIH) and Eisai Inc., a U.S. subsidiary of Eisai Co., Ltd. (Headquarters: Tokyo), the AHEAD Study is the first Alzheimer's disease research study to recruit people as young as 55 years old who are at risk of developing symptoms of Alzheimer's disease as they get older. It introduces a personalized approach that will tailor treatment dosing levels to a participant's particular risk of memory loss related to Alzheimer's disease.

The AHEAD Study consists of two different clinical trials testing the same investigational treatment (known as BAN2401 (lecanemab)). Participants are enrolled in one of the two trials based on the level of amyloid in their brain. Amyloid is a protein that builds up in people who can go on to have memory problems and develop Alzheimer's disease.

"The tailored approach of this study, starting treatment years before memory loss has begun, has the potential to be a breakthrough step in our aim to prevent Alzheimer's disease," said William R. Shankle, M.S., M.D., F.A.C.P., program director of Memory & Cognitive Disorders at Hoag and The Judy and Richard Voltmer Chair in Memory and Cognitive Disorders at the Pickup Family Neurosciences Institute, who is serving as the principal investigator of the study at Hoag. "It can potentially serve as a model to improve future clinical trials in Alzheimer's research and other diseases."

The AHEAD Study will be conducted in the US, Japan, Canada, Australia, Singapore, and Europe. Hoag was selected to participate in the parallel, 216-week study in part because of its renowned Orange County Vital Brain Aging Program and our track record of successfully conducting complex clinical studies.

"Hoag's Pickup Family Neurosciences Institute has pioneered a comprehensive program to maintain cognitive health as we age, and to combat the community's fear of Alzheimer's disease and related disorders, through the Orange County Vital Brain Program," said Michael Brant-Zawadzki, M.D., F.A.C.R., Hoag's senior physician executive and the Ron & Sandi Simon Executive Medical Director Endowed Chair of the Pickup Family Neurosciences Institute. "As a result, we are able to offer our community unique opportunities to participate in studies like the AHEAD Study. This is well-aligned with the mission of our Institute, and we are very excited to be a part of this pioneering effort to help identify ways to prevent Alzheimer's disease."

People may be eligible to enroll in the trial if they are between the ages of 55 and 80 and meet certain eligibility criteria. For more information on the study and the study participation, please email clinicalresearch@hoag.org.

Research reported in this press release was supported by the NIH's National Institute on Aging under award numbers R01AG054029 and R01AG061848. The AHEAD Study (Clinical Trial number NCT04468659) received funding from NIH and from nongovernmental sources. The content is solely the responsibility of the researchers and does not necessarily represent the official views of the National Institutes of Health.

ABOUT PICKUP FAMILY NEUROSCIENCES INSTITUTE
Compassionate Care, Clinical Excellence, Creative Intelligence
Hoag and the Pickup Family Neurosciences Institute were ranked by U.S. News & World Report as the No. 1 hospital in Orange County and No. 27 nationally in Neurology & Neurosurgery, placing it in the top 1% of neuro-specialist programs across the U.S., and the only one in the top 30 without a formal university residency curriculum. Delivering a personalized, integrated approach using best-practice guidelines, the most advanced technology, and integration of medical specialists in the most appropriate facilities, the Pickup Family Neurosciences Institute (PFNI) at Hoag provides world class care for patients with specific conditions of the brain and spine such as stroke, aneurysms and vascular malformations, brain tumors, epilepsy, movement disorders, memory and cognitive disorders, pain, minimally invasive spine surgery, multiple sclerosis, addiction medicine and sleep disorders, as well as the mind-body interface of mental health. Many of Hoag's PFNI programs have received high acclaim.The Hoag Stroke Program was the first in Orange County and the second in California to be named a Certified Comprehensive Stroke Center by DNV GL Healthcare and was awarded the American Stroke Association's Get With The Guidelines Stroke Gold Plus Performance Achievement for stroke care. And as one of the first centers in the U.S. to offer the most advanced radiosurgical treatment system available, Leksell Gamma Knife® Perfexion, the PFNI brain tumor program is the largest in Orange County and is also among the top volume programs in the western United States. Hoag has been recognized as a designated Level 4 Comprehensive Epilepsy Center by the National Association of Epilepsy Centers. The PFNI's memory and cognitive disorders program is nationally recognized.

ABOUT HOAG
Hoag is a nonprofit, regional health care delivery network in Orange County, California, that treats more than 30,000 inpatients and 480,000 outpatients annually. Hoag consists of two acute-care hospitals – Hoag Hospital Newport Beach, which opened in 1952, and Hoag Hospital Irvine, which opened in 2010 – in addition to nine health centers and 13 urgent care centers. Hoag has invested $261 million in programs and services to support the underserved community within the past five years, including areas like mental health, homelessness, transportation for seniors, education, and support for single mothers. Hoag is a designated Magnet® hospital by the American Nurses Credentialing Center (ANCC). Hoag offers a comprehensive blend of health care services that includes five institutes providing specialized services in the following areas: cancerheart and vascularneuroscienceswomen's health, and orthopedics through Hoag's affiliate, Hoag Orthopedic Institutewhich consists of an orthopedic hospital and two ambulatory surgical centers. In the 2020 - 2021 U.S. News & World Report Best Hospitals Rankings, Hoag is the highest ranked hospital in Orange County and the only OC hospital ranked in the Top 10 in California. For an unprecedented 23 years, residents of Orange County have chosen Hoag as one of the county's best hospitals in a local newspaper survey. Visit www.hoag.org for more information.

 

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SOURCE Hoag Memorial Hospital Presbyterian

 

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