Oligonucleotide Synthesis Market Outlook, Competitive Landscape and Forecasts to 2027

Wilmington, Delaware, United States: According to Transparency Market Research’s latest report on the global oligonucleotide synthesis market for the historical period 2017–2018 and forecast period 2019–2027, Increasing use of synthesized oligonucleotides in diagnostics and research applications, and Technological advancements in synthetic chemistry are projected to drive the global oligonucleotide synthesis market during the forecast period

According to the report, the global oligonucleotide synthesis market was valued at US$ 1,966.2 Mn in 2018 and is anticipated to expand at a CAGR of 9.5% from 2019 to 2027

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Technological advancements in synthetic chemistry to Drive Global Oligonucleotide Synthesis: Key Drivers

The advances in the technological development of organic molecules are expected to drive the growth of the oligonucleotide synthesis market

The advanced synthesis of oligonucleotides provides longer oligos with better sequence fidelity and higher purity that can be used in a number of molecular biology applications

Various pharmaceutical and biotechnology companies are continuously working on developing newer and advanced methods in synthetic chemistry

For instance, Integrated DNA Technologies, leader of synthesized oligonucleotides has developed various pioneered methods to synthesize oligonucleotides of extreme lengths. The company has developed oligonucleotides up to 200 base length which is used with mass spectrometry for the manufacture of mini-genes.

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Increasing use of Synthesized Oligonucleotides in Diagnostics and Research Applications Boost Market Growth

Oligonucleotides have a wide range of applications in areas such as molecular biology, biotechnology, and diagnosis

Natural oligonucleotides have been extensively used for the selection and determination of DNA sequences (hybridization probes or affinity purification), gene construction, and site-directed mutagenesis

They constitute the basic reagents for PCR technologies. They are also used to selectively inhibit gene expression in in vitro studies for diagnostic purpose and more recently, their ability to interact with proteins has generated immense opportunity for therapeutic use.

Along with diagnostics, they are widely used in research studies. Combinatorial technology is another research area where oligonucleotides and their analogs are extensively employed.

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Limitations in the Synthesis of Oligonucleotides to Hamper Market

An oligonucleotide is a single-stranded chain consisting of a number of nucleoside units linked together by phosphodiester bridges

Mostly in oligonucleotide synthesis, phosphodiesters are formed between a 3’-hydroxyl group bearing a phosphate derivative and a 5’-hydroxyl group of another nucleoside

The occurrence of side reactions sets practical limits for the length of synthetic DNA oligonucleotides (up to about 200 nucleotide residues) because the number of errors accumulates with the length of the oligonucleotide being synthesized

To synthesize RNA with longer nucleotides base, that is more than 50 nucleotides is very complex and difficult to prepare

But, most biologically important RNA molecules such as ribozymes, aptamers, and riboswitches are significantly longer than 50 nucleotides, so new approaches for the synthesis of RNA analogs are urgently required

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Global Oligonucleotide Synthesis Market: Competitive Landscape

This report profiles major players in the global oligonucleotide synthesis market based on various attributes such as company overview, financial overview, product portfolio, business strategies, and recent developments

The global oligonucleotide synthesis market is highly fragmented, with the presence of a number of international as well as regional players

Leading players operating in the global Oligonucleotide Synthesis market are

  • GE Healthcare
  • Thermo Fischer Scientific
  • Agilent Technologies, Inc.
  • Merck KGaA
  • Integrated DNA Technologies, Inc.
  • Kaneka Eurogentec S.A
  • BioAutomation
  • Gene Design, Inc.
  • Eurofins Genomics
  • ATDBio, Ltd..

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