BETHESDA, Md., Jan. 27, 2015 (GLOBE NEWSWIRE) -- A joint effort by The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF) and the Uniformed Services University of the Health Sciences (USU) to license assays that allow for the rapid detection of Shiga toxin has received the 2015 Federal Laboratory Consortium Award for Excellence in Technology Transfer. This marks the third consecutive award for the University, which is aided in its technology transfer efforts by HJF through the USU-HJF Joint Office of Technology Transfer.
The award is for work on Shiga toxin-producing Escherichia coli by Alison O’Brien, Ph.D., professor and chair of USU’s Microbiology and Immunology Department, and her colleagues. The Federal Laboratory Consortium, a nationwide network of federal laboratories that seeks to develop strategies and opportunities for linking technologies and expertise with the marketplace, will present the award in April.
Two strains of the Shiga toxin are responsible for approximately 265,000 intestinal infections each year in the U.S. The strains have caused multiple food-borne outbreaks prompted by the consumption of undercooked meat, raw milk, lettuce, spinach and other foods. Such infections can result in acute diarrhea, hemorrhagic colitis, and in 5 percent to 10 percent of cases, life-threatening hemolytic uremic syndrome.
The research done by Dr. O’Brien and her colleagues addressed a key challenge in diagnosing the disease. Previously, such diagnoses were hampered by the slowness of culturing methods, which could take 24 hours or more to complete, and the difficulty of diagnosing certain strains by culturing. Further, existing detection kits did not provide the sensitivity necessary for rapid same-day testing of samples or diagnosis at physicians’ offices and clinics.
These issues were addressed when USU researchers developed two assay formats that can detect Shiga toxin produced by multiple strains of E. coli. The first is a detection technology used in food and clinical samples, while the second is a diagnostic assay that uses monoclonal antibodies, developed at USU, to detect Shiga toxins. As a result of the research, rapid tests are now able to detect and differentiate the toxins in about 30 minutes, allowing timely diagnosis of Shiga toxin-producing E. coli and the implementation of appropriate treatment plans.
“HJF has been proud to support Alison O’Brien’s Shiga toxin research since 1983, the year our company was founded. The work by Dr. O’Brien and others stands as an important achievement that illustrates the frequently untold story about military medicine’s commitment to sharing its advances with the civilian world,” said John W. Lowe, HJF President and CEO. “Congratulations to Dr. O’Brien and our respected colleagues at USU on this recognition of their efforts.”
The Shiga toxin diagnostic technology was successfully transferred under a license to Alere, a company with a focus on innovative rapid diagnostic products. The products have been licensed as Shiga Toxin Chek and Shiga Toxin Quik Chek. To further the development of the Shiga toxin technology into a commercial product, a cooperative research and development agreement with Alere and TechLab®, a sublicensee of Alere, was executed by the USU-HJF Joint Office of Technology Transfer. The efforts of Dr. O’Brien, lead USU inventor of the technology, and Louise Teel, Ph.D., principal investigator on the agreement and an inventor of the technology, as well as representatives from USU’s Office of the General Counsel and HJF’s Technology Transfer team, were key to the successful negotiation of the agreement for transfer of the technology. Dr. Teel is an associate professor in USU’s Microbiology and Immunology Department.
The Foundation and the University created the USU-HJF Joint Office of Technology Transfer in 2000 to help scientists at the University and the Foundation move their novel inventions, devices and technologies to possible patenting and commercialization. The office serves as the technology transfer office for USU and supports University research through agreement negotiation and management, patent filings, and licensing and marketing of technologies.
The Federal Laboratory Consortium’s Award for Excellence in Technology Transfer recognizes employees of its member laboratories and non-laboratory staff members who have accomplished outstanding work in the process of transferring federally developed technology to the commercial marketplace. A panel of experts from industry, state and local government, academia, and the federal laboratory system judge the nominations.
About HJF
The Henry M. Jackson Foundation for the Advancement of Military Medicine is a private, not-for-profit organization established in 1983 and authorized by Congress to support medical research and education at the Uniformed Services University of the Health Sciences and throughout the broader military medical community. For more information, visit www.hjf.org.
Contact: JoAnn Sperber, HJF Director of Communications, 240-694-2163, jsperber@hjf.org
About Alere
Because Knowing now matters™, Alere delivers reliable and actionable information through rapid diagnostic tests, resulting in better clinical and economic healthcare outcomes globally. Headquartered in Waltham, Mass., Alere focuses on rapid diagnostics for infectious disease, cardiometabolic disease and toxicology. For more information on Alere, please visit www.alere.com
About TechLab
Founded in 1989, TECHLAB® Inc. is a global leader in developing and manufacturing premium diagnostics for diarrheal diseases. TECHLAB research teams focus on enteric diseases and the microbiology of the intestinal tract. TECHLAB offers diagnostic kits for colitis, parasitology, intestinal inflammation, and Shiga toxins. Headquartered in Blacksburg, Virginia, TECHLAB is dedicated to excellence in its diagnostics and research. TECHLAB diagnostic kits are available through its distributor and partner, Alere™, a leading global provider of diagnostic products and health information solutions. Together, TECHLAB and Alere provide high quality, rapid diagnostics for your enteric needs.
CONTACT: JoAnn Sperber 240-694-2163 jsperber@hjf.org
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