Advanced Life Sciences Holdings, Inc. Regains Compliance With Nasdaq Listing Requirements

CHICAGO, April 16 /PRNewswire-FirstCall/ -- Advanced Life Sciences Holdings, Inc. , today announced that it has regained compliance with the Nasdaq Capital Market listing requirements. On April 16, 2008, the Company received notification from the Nasdaq Listing Qualification Department that it has regained compliance with Nasdaq Marketplace Rule 4310(c)(4) because the closing bid price of the Company’s common stock has been equal to or in excess of $1.00 for a minimum of ten consecutive business days.

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About Advanced Life Sciences

Advanced Life Sciences is a biopharmaceutical company engaged in the discovery, development and commercialization of novel drugs in the therapeutic areas of infection, cancer and respiratory diseases. The Company’s lead candidate, cethromycin, is a novel once-a-day oral antibiotic in late-stage development for the treatment of respiratory tract infections including community acquired pneumonia (CAP). For more information, please visit us on the web at http://www.advancedlifesciences.com.

Forward-Looking Statements

Any statements contained in this press release that relate to future plans, events or performance are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements represent our management’s judgment regarding future events. The Company does not undertake any obligations to update any forward-looking statements whether as a result of new information, future events or otherwise. Our actual results could differ materially from those discussed herein due to several factors including the our ability to obtain and maintain regulatory approval and labeling of our product candidates; our plans to develop and commercialize our product candidates; the loss of key scientific or management personnel; the size and growth of potential markets for our product candidates and our ability to serve those markets; regulatory developments in the U.S. and foreign countries; the rate and degree of market acceptance of any future products; the accuracy of our estimates regarding expenses, future revenues and capital requirements; our ability to obtain financing on terms acceptable to us; our ability to obtain and maintain intellectual property protection for our product candidates; the successful development of our sales and marketing capabilities; the success of competing drugs that become available; and the performance of third party collaborators and manufacturers. These and additional risks and uncertainties are detailed in the Company’s filings with the Securities and Exchange Commission.

CONTACT: company, Joe Camp of Advanced Life Sciences Holdings, Inc.,
+1-630-754-4352, jcamp@advancedlifesciences.com; or media, Melanie Nimrodi,
+1-312-546-3508, mnimrodi@frbir.com, or investors, Kathy Price,
+1-213-486-6547, kprice@frbir.com, both of Financial Relations Board for
Advanced Life Sciences Holdings, Inc.

Web site: http://www.advancedlifesciences.com/

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