Vertex Pharmaceuticals Incorporated Announces Webcasts Of Its Presentations At Two Investor Conferences

CAMBRIDGE, Mass., April 28 /PRNewswire-FirstCall/ -- Vertex Pharmaceuticals Incorporated will webcast its presentations at Deutsche Bank’s 31st Annual Health Care Conference on May 2, 2006 and at Morgan Stanley’s Global Healthcare Unplugged Conference on May 4, 2006.

Joshua Boger, Ph.D., Chairman, President and Chief Executive Officer of Vertex, will present at the Deutsche Bank Health Care Conference on Tuesday, May 2, 2006 at 4:00 p.m. EDT and will also participate in an HCV Panel at 4:45 p.m. EDT.

Ian Smith, Executive Vice President and Chief Financial Officer of Vertex, will present at the Morgan Stanley Global Healthcare Conference. The presentation and discussion will be conducted on Thursday, May 4, 2006 at 8:00 a.m. EDT.

The presentations will be webcast live and may be accessed by visiting the Vertex website at http://www.vrtx.com. A replay of the webcasts will also be available on the Company’s website for two weeks following the presentations. To access the webcasts, go to Vertex’s website and select the ‘Deutsche Bank 31st Annual Health Care Conference’ or the ‘Deutsche Bank HCV Panel’ or the ‘Morgan Stanley 2006 Global Healthcare Unplugged Conference’ from the ‘Events Calendar.’ To ensure a timely connection, it is recommended that users register at least 15 minutes prior to the scheduled webcast.

About Vertex

Vertex Pharmaceuticals Incorporated is a global biotechnology company committed to the discovery and development of breakthrough small molecule drugs for serious diseases. The Company’s strategy is to commercialize its products both independently and in collaboration with major pharmaceutical companies. Vertex’s product pipeline is principally focused on viral diseases, inflammation, autoimmune diseases and cancer. In collaboration with GlaxoSmithKline, Vertex co-promotes the HIV protease inhibitor, Lexiva.

Lexiva is a registered trademark of the GlaxoSmithKline group of companies.

Vertex’s press releases are available at http://www.vrtx.com. Vertex Contact: Lora Pike, Manager, Investor Relations, (617) 444-6755

Vertex Pharmaceuticals Incorporated

CONTACT: Lora Pike, Manager, Investor Relations of Vertex, +1-617-444-6755

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