Researchers led by a team at the University of California, San Diego, School of Medicine have determined that overexpression of the ADAR1 enzyme, which is responsible for RNA editing, ramps up cellular regeneration, causing white blood cell precursors to develop into leukemia stem cells. Even more significantly, the investigators determined that a small-molecule tool could counteract the overexpression of ADAR1 and reduce the regeneration of leukemia cells.
