Skyepharma PLC Press Announcement

LONDON, July 28 /PRNewswire-FirstCall/ -- In compliance with NASDAQ Marketplace Rule 4350 (b)1(B) SkyePharma PLC announces that the independent audit report included in the Company’s UK Annual Report and Annual Report on Form 20-F for the year ended 31 December 2005 contained an explanatory paragraph relating to the Company’s ability to continue as a going concern. Management plans with regard to these matters are described in Note 1 to the financial statements. The disclosure in this press release is required under the aforementioned NASDAQ rule and does not represent any change to the Company’s Annual Reports for the year ended 31 December 2005.

For further information please contact: SkyePharma PLC +44 207 491 1777 Peter Laing, Director of Corporate Communications 44 207 491 5124 Sandra Haughton, US Investor Relations +1 212 753 5780 Buchanan Communications +44 207 466 5000 Tim Anderson / Mark Court / Rebecca Skye Dietrich About SkyePharma

SkyePharma PLC develops pharmaceutical products benefiting from world- leading drug delivery technologies that provide easier-to-use and more effective drug formulations. There are now twelve approved products incorporating SkyePharma’s technologies in the areas of oral, injectable, inhaled and topical delivery, supported by advanced solubilisation capabilities. For more information, visit

Certain statements in this news release are forward-looking statements and are made in reliance on the safe harbour provisions of the U.S. Private Securities Litigation Act of 1995. Although SkyePharma believes that the expectations reflected in these forward-looking statements are reasonable, it can give no assurance that these expectations will materialize. Because the expectations are subject to risks and uncertainties, actual results may vary significantly from those expressed or implied by the forward-looking statements based upon a number of factors, which are described in SkyePharma’s 20-F and other documents on file with the SEC. Factors that could cause differences between actual results and those implied by the forward-looking statements contained in this news release include, without limitation, risks related to the development of new products, risks related to obtaining and maintaining regulatory approval for existing, new or expanded indications of existing and new products, risks related to SkyePharma’s ability to manufacture products on a large scale or at all, risks related to SkyePharma’s and its marketing partners’ ability to market products on a large scale to maintain or expand market share in the face of changes in customer requirements, competition and technological change, risks related to regulatory compliance, the risk of product liability claims, risks related to the ownership and use of intellectual property, and risks related to SkyePharma’s ability to manage growth. SkyePharma undertakes no obligation to revise or update any such forward-looking statement to reflect events or circumstances after the date of this release.

SkyePharma PLC

CONTACT: Peter Laing, Director of Corporate Communications,+44-207-491-5124, or Sandra Haughton, US Investor Relations,+1-212-753-5780, all of SkyePharma PLC, +44-207-491-1777; or Tim Anderson,Mark Court, Rebecca Skye Dietrich, all of Buchanan Communications,+44-207-466-5000