SUNNYVALE, Calif. & NEW YORK--(BUSINESS WIRE)--SAFE-BioPharma Association and Arcot Systems today announced that AstraZeneca, a major international healthcare business, has become the first company to send digitally-signed submissions to the FDA. AstraZeneca which is engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and is a supplier of healthcare services, has committed to the digital workflow process using the SAFE (Signatures and Authentication for Everyone) digital identity and signature standard in combination with authentication software from Arcot Systems.