Results of a small study show that obese men who take a small daily dose of the supplement resveratrol -- found as a natural compound in red wine -- appear to improve their metabolism as much as if they were on a strict low-calorie diet.Animal studies have previously found that resveratrol reduces insulin resistance and protects against the bad effects of a high-fat diet. This is similar to what happens when people restrict the number of calories they take in, which has been shown to delay the onset of age-related diseases, the Dutch researchers say.