London, UK; Brentwood, TN, US; 18 June 2007 - Protherics PLC ("Protherics" or
the "Company"), the international biopharmaceutical company focused on critical
care and cancer, announces that, on 18 June 2007, a notification of interest in
the ordinary share capital of the Company was received from INVESCO plc in
accordance with the Transparency Obligations Directive. Details of the interest
are as follows: