Protherics PLC - Holding(s) in Company

Cheshire, UK--(Marketwire - August 29, 2008) - London, UK; Brentwood, TN, US: 29 August 2008 - Protherics PLC (“Protherics” or the “Company”), the international biopharmaceutical company focused on critical care and cancer, announces that today, in accordance with the Transparency Obligations Directive, a notification of interest in the ordinary share capital of the Company was received from Invesco Perpetual on behalf of Invesco Limited.

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