CHESHIRE, UK--(Marketwire - July 04, 2008) - Protherics PLC: Issue of Shares London, UK; Brentwood, TN, US: 4 July 2008 - Protherics PLC (“Protherics” or the “Company”), the international biopharmaceutical company focused on critical care and cancer, announces that the Company has today issued 1,741,911 ordinary shares pursuant to the MacroMed Acquisition Agreement (“Agreement”) approved by shareholders at the Company’s Extraordinary General Meeting held on 3 January 2007 and details of which were contained in the Company’s announcement dated 7 December 2006.